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001     169932
005     20240229133700.0
020 _ _ |a 978-3-030-62657-0 (print)
020 _ _ |a 978-3-030-62658-7 (electronic)
024 7 _ |a 10.1007/978-3-030-62658-7_1
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024 7 _ |a pmid:34286437
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024 7 _ |a 0065-2598
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024 7 _ |a 2214-8019
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024 7 _ |a doi: 10.1007/978-3-030-62658-7_1
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037 _ _ |a DKFZ-2021-01638
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a O'Connor, Tracy Lynn
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245 _ _ |a CCL2 in the Tumor Microenvironment.
260 _ _ |a [Heidelberg]
|c 2021
|b Springer
336 7 _ |a article
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520 _ _ |a The C-C motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment during microbial infections and tissue damage. CCL2 is also frequently overexpressed in cancer cells and other cells in the tumor microenvironment, and a large body of evidence indicates that high CCL2 levels are associated with more aggressive malignancies, a higher probability of metastasis, and poorer outcomes in a wide range of cancers. CCL2 plays a role in recruiting tumor-associated macrophages (TAMs), which adopt a pro-tumorigenic phenotype and support cancer cell survival, facilitate tumor cell invasion, and promote angiogenesis. CCL2 also has direct, TAM-independent effects on tumor cells and the tumor microenvironment, including recruitment of other myeloid subsets and non-myeloid cells, maintaining an immunosuppressive environment, stimulating tumor cell growth and motility, and promoting angiogenesis. CCL2 also plays important roles in the metastatic cascade, such as creating a pre-metastatic niche in distant organs and promoting tumor cell extravasation across endothelia. Due to its many roles in tumorigenesis and metastatic processes, the CCL2-CCR2 signaling axis is currently being pursued as a potential therapeutic target for cancer.
536 _ _ |a 316 - Infektionen, Entzündung und Krebs (POF4-316)
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588 _ _ |a Dataset connected to CrossRef Book Series, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
650 _ 7 |a Angiogenesis
|2 Other
650 _ 7 |a CCL2
|2 Other
650 _ 7 |a CCR2
|2 Other
650 _ 7 |a Cancer
|2 Other
650 _ 7 |a Extravasation
|2 Other
650 _ 7 |a Immunity
|2 Other
650 _ 7 |a Immunosuppression
|2 Other
650 _ 7 |a Invasion
|2 Other
650 _ 7 |a MCP-1
|2 Other
650 _ 7 |a Macrophage
|2 Other
650 _ 7 |a Metastasis
|2 Other
650 _ 7 |a Microenvironment
|2 Other
650 _ 7 |a NFκB
|2 Other
650 _ 7 |a TAM
|2 Other
650 _ 7 |a Tumor
|2 Other
650 _ 7 |a Chemokine CCL2
|2 NLM Chemicals
650 _ 7 |a Chemokines
|2 NLM Chemicals
650 _ 7 |a Ligands
|2 NLM Chemicals
650 _ 7 |a Receptors, CCR2
|2 NLM Chemicals
650 _ 2 |a Cell Line, Tumor
|2 MeSH
650 _ 2 |a Chemokine CCL2: genetics
|2 MeSH
650 _ 2 |a Chemokines
|2 MeSH
650 _ 2 |a Ligands
|2 MeSH
650 _ 2 |a Receptors, CCR2: genetics
|2 MeSH
650 _ 2 |a Tumor Microenvironment
|2 MeSH
700 1 _ |a Heikenwälder, Mathias
|0 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5
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773 _ _ |a 10.1007/978-3-030-62658-7_1
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909 C O |o oai:inrepo02.dkfz.de:169932
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910 1 _ |a Deutsches Krebsforschungszentrum
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914 1 _ |y 2021
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