%0 Journal Article
%A Carles, Montserrat
%A Fechter, Tobias
%A Grosu, Anca L
%A Sörensen, Arnd
%A Thomann, Benedikt
%A Stoian, Raluca
%A Wiedenmann, Nicole
%A Rühle, Alexander
%A Zamboglou, Constantinos
%A Ruf, Juri
%A Martí-Bonmatí, Luis
%A Baltas, Dimos
%A Mix, Michael
%A Nicolay, Nils H
%T 18F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy.
%J Cancers
%V 13
%N 14
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2021-01663
%P 3449
%D 2021
%X Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by 18F-fluoromisonidazole (18F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of 18F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT and longitudinal 18F-FMISO-PET/CT scans at weeks 0, 2 and 5 (W0/W2/W5). Patients were classified based on peritherapeutic variations of the hypoxic sub-volume (HSV) size (increasing/stable/decreasing) and location (geographically-static/geographically-dynamic) by a new objective classification parameter (CP) accounting for spatial overlap. Additionally, 130 radiomic features (RF) were extracted from HSV at W0, and their variations during CRT were quantified by relative deviations (∆RF). Prediction of treatment outcome was considered statistically relevant after being corrected for multiple testing and confirmed for the two 18F-FMISO-PET/CT time-points and for a validation cohort. HSV decreased in 64
%K 18F-FMISO-PET (Other)
%K head-and-neck squamous cell carcinoma and radiomics (Other)
%K hypoxia (Other)
%K radiotherapy response monitoring (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34298663
%R 10.3390/cancers13143449
%U https://inrepo02.dkfz.de/record/169963