TY  - JOUR
AU  - Carles, Montserrat
AU  - Fechter, Tobias
AU  - Grosu, Anca L
AU  - Sörensen, Arnd
AU  - Thomann, Benedikt
AU  - Stoian, Raluca
AU  - Wiedenmann, Nicole
AU  - Rühle, Alexander
AU  - Zamboglou, Constantinos
AU  - Ruf, Juri
AU  - Martí-Bonmatí, Luis
AU  - Baltas, Dimos
AU  - Mix, Michael
AU  - Nicolay, Nils H
TI  - 18F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy.
JO  - Cancers
VL  - 13
IS  - 14
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-01663
SP  - 3449
PY  - 2021
AB  - Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by 18F-fluoromisonidazole (18F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of 18F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT and longitudinal 18F-FMISO-PET/CT scans at weeks 0, 2 and 5 (W0/W2/W5). Patients were classified based on peritherapeutic variations of the hypoxic sub-volume (HSV) size (increasing/stable/decreasing) and location (geographically-static/geographically-dynamic) by a new objective classification parameter (CP) accounting for spatial overlap. Additionally, 130 radiomic features (RF) were extracted from HSV at W0, and their variations during CRT were quantified by relative deviations (∆RF). Prediction of treatment outcome was considered statistically relevant after being corrected for multiple testing and confirmed for the two 18F-FMISO-PET/CT time-points and for a validation cohort. HSV decreased in 64
KW  - 18F-FMISO-PET (Other)
KW  - head-and-neck squamous cell carcinoma and radiomics (Other)
KW  - hypoxia (Other)
KW  - radiotherapy response monitoring (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34298663
DO  - DOI:10.3390/cancers13143449
UR  - https://inrepo02.dkfz.de/record/169963
ER  -