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| Home > Publications database > 18F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy. > print |
| Home > Publications database > 18F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy. > print |
| 001 | 169963 | ||
| 005 | 20240229133701.0 | ||
| 024 | 7 | _ | |a 10.3390/cancers13143449 |2 doi |
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| 037 | _ | _ | |a DKFZ-2021-01663 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Carles, Montserrat |0 0000-0003-2401-8240 |b 0 |
| 245 | _ | _ | |a 18F-FMISO-PET Hypoxia Monitoring for Head-and-Neck Cancer Patients: Radiomics Analyses Predict the Outcome of Chemo-Radiotherapy. |
| 260 | _ | _ | |a Basel |c 2021 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Tumor hypoxia is associated with radiation resistance and can be longitudinally monitored by 18F-fluoromisonidazole (18F-FMISO)-PET/CT. Our study aimed at evaluating radiomics dynamics of 18F-FMISO-hypoxia imaging during chemo-radiotherapy (CRT) as predictors for treatment outcome in head-and-neck squamous cell carcinoma (HNSCC) patients. We prospectively recruited 35 HNSCC patients undergoing definitive CRT and longitudinal 18F-FMISO-PET/CT scans at weeks 0, 2 and 5 (W0/W2/W5). Patients were classified based on peritherapeutic variations of the hypoxic sub-volume (HSV) size (increasing/stable/decreasing) and location (geographically-static/geographically-dynamic) by a new objective classification parameter (CP) accounting for spatial overlap. Additionally, 130 radiomic features (RF) were extracted from HSV at W0, and their variations during CRT were quantified by relative deviations (∆RF). Prediction of treatment outcome was considered statistically relevant after being corrected for multiple testing and confirmed for the two 18F-FMISO-PET/CT time-points and for a validation cohort. HSV decreased in 64% of patients at W2 and in 80% at W5. CP distinguished earlier disease progression (geographically-dynamic) from later disease progression (geographically-static) in both time-points and cohorts. The texture feature low grey-level zone emphasis predicted local recurrence with AUCW2 = 0.82 and AUCW5 = 0.81 in initial cohort (N = 25) and AUCW2 = 0.79 and AUCW5 = 0.80 in validation cohort. Radiomics analysis of 18F-FMISO-derived hypoxia dynamics was able to predict outcome of HNSCC patients after CRT. |
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| 650 | _ | 7 | |a 18F-FMISO-PET |2 Other |
| 650 | _ | 7 | |a head-and-neck squamous cell carcinoma and radiomics |2 Other |
| 650 | _ | 7 | |a hypoxia |2 Other |
| 650 | _ | 7 | |a radiotherapy response monitoring |2 Other |
| 700 | 1 | _ | |a Fechter, Tobias |0 0000-0001-6271-9385 |b 1 |
| 700 | 1 | _ | |a Grosu, Anca L |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Sörensen, Arnd |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Thomann, Benedikt |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Stoian, Raluca |0 P:(DE-He78)75b4c256a6de824414938cf2aaeff88e |b 5 |
| 700 | 1 | _ | |a Wiedenmann, Nicole |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Rühle, Alexander |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Zamboglou, Constantinos |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Ruf, Juri |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Martí-Bonmatí, Luis |0 0000-0002-8234-010X |b 10 |
| 700 | 1 | _ | |a Baltas, Dimos |0 0000-0003-4220-9083 |b 11 |
| 700 | 1 | _ | |a Mix, Michael |0 0000-0002-9106-2519 |b 12 |
| 700 | 1 | _ | |a Nicolay, Nils H |0 P:(DE-HGF)0 |b 13 |e Last author |
| 773 | _ | _ | |a 10.3390/cancers13143449 |g Vol. 13, no. 14, p. 3449 - |0 PERI:(DE-600)2527080-1 |n 14 |p 3449 |t Cancers |v 13 |y 2021 |x 2072-6694 |
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