TY  - JOUR
AU  - Gies, Anton
AU  - Niedermaier, Tobias
AU  - Alwers, Elizabeth
AU  - Hielscher, Thomas
AU  - Weigl, Korbinian
AU  - Heisser, Thomas
AU  - Schrotz-King, Petra
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Consistent Major Differences in Sex- and Age-Specific Diagnostic Performance among Nine Faecal Immunochemical Tests Used for Colorectal Cancer Screening.
JO  - Cancers
VL  - 13
IS  - 14
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-01675
SP  - 3574 -
PY  - 2021
N1  - #EA:C120#LA:C070#
AB  - Evidence on diagnostic performance of faecal immunochemical tests (FITs) by sex and age is scarce. We aimed to evaluate FIT performance for detection of advanced colorectal neoplasia (AN) by sex and age across nine different FIT brands in a colonoscopy-controlled setting. The faecal samples were obtained from 2042 participants of colonoscopy screening. All eligible cases with AN (n = 216) and 300 randomly selected participants without AN were included. Diagnostic performance for detection of AN was assessed by sex and age (50-64 vs. 65-79 years for each of the nine FITs individually and for all FITs combined. Sensitivity was consistently lower, and specificity was consistently higher for females as compared with males (pooled values at original FIT cutoffs, 25.7
KW  - colon cancer (Other)
KW  - early detection (Other)
KW  - faecal occult blood test (Other)
KW  - prevention (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34298786
DO  - DOI:10.3390/cancers13143574
UR  - https://inrepo02.dkfz.de/record/169975
ER  -