%0 Journal Article
%A Drake, Virginia
%A Bigelow, Elaine
%A Fakhry, Carole
%A Windon, Melina
%A Rooper, Lisa M
%A Ha, Patrick
%A Miles, Brett
%A Gourin, Christine
%A Mandal, Rajarsi
%A Mydlarz, Wojciech
%A London, Nyall
%A Vosler, Peter S
%A Yavvari, Siddhartha
%A Troy, Tanya
%A Waterboer, Tim
%A Eisele, David W
%A D'Souza, Gypsyamber
%T Biologic and behavioral associations of estrogen receptor alpha positivity in head and neck squamous cell carcinoma.
%J Oral oncology
%V 121
%@ 1368-8375
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2021-01685
%P 105461
%D 2021
%Z 2021 Oct;121:105461
%X Tumor HPV status is an established independent prognostic marker for oropharynx cancer (OPC). Recent studies have reported that tumor estrogen receptor alpha (ERα) positivity is also associated with prognosis independent of HPV. Little is known about the biologic and behavioral predictors of ERα positivity in head and neck squamous cell cancer (HNSCC). We therefore explored this in a multicenter prospective cohort study.Participants with HNSCC completed a survey and provided a blood sample. Tumor samples were tested for ERα using immunohistochemistry. ERα positivity was defined as ≥1
%K Estrogen receptor alpha (Other)
%K Head and neck neoplasms (Other)
%K Oropharyngeal neoplasms (Other)
%K Papillomaviridae (Other)
%K Tumor biomarkers (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34304004
%R 10.1016/j.oraloncology.2021.105461
%U https://inrepo02.dkfz.de/record/169985