TY  - JOUR
AU  - Li, Hengjing
AU  - Boakye, Daniel
AU  - Chen, Xuechen
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Association of Body Mass Index With Risk of Early-Onset Colorectal Cancer: Systematic Review and Meta-Analysis.
JO  - The American journal of gastroenterology
VL  - 116
IS  - 11
SN  - 1572-0241
CY  - Alphen aan den Rijn, The Netherlands
PB  - Wolters Kluwer Health, Inc.
M1  - DKFZ-2021-01695
SP  - 2173-2183
PY  - 2021
N1  - #EA:C070#LA:C070# / 2021 Nov 1;116(11):2173-2183
AB  - Incidence of colorectal cancer (CRC) in young adults has been increasing in recent decades in many countries for still widely unclear reasons. Suspected candidates include increasing prevalence of overweight and obesity, but specific evidence on their role for early-onset CRC (EOCRC) is sparse. We conducted a systematic review and meta-analysis to summarize available evidence on the association of body mass index (BMI) with EOCRC.We systematically searched PubMed, EMBASE, and Web of Science up to February 2021 for studies that evaluated the association of BMI (before diagnosis but not near diagnosis) with CRC risk and reported specific results for EOCRC. Results from studies with similar BMI groupings were summarized in meta-analyses using random-effects models.Twelve studies were eligible and included. Results of 6 studies were pooled in meta-analyses, which yielded a higher risk of EOCRC for overweight and obesity (BMI ≥25 kg/m2) compared with normal weight (odds ratio [OR] 1.42, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:34309586
DO  - DOI:10.14309/ajg.0000000000001393
UR  - https://inrepo02.dkfz.de/record/169996
ER  -