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@ARTICLE{Li:170064,
      author       = {X. Li$^*$ and P. Ramadori$^*$ and D. Pfister$^*$ and M.
                      Seehawer and L. Zender$^*$ and M. Heikenwälder$^*$},
      title        = {{T}he immunological and metabolic landscape in primary and
                      metastatic liver cancer.},
      journal      = {Nature reviews / Cancer},
      volume       = {21},
      issn         = {1474-1768},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2021-01733},
      pages        = {541–557},
      year         = {2021},
      note         = {#EA:F180#LA:F180# / 21, pages 541–557 (2021) /
                      #DKFZ-MOST-Ca197#},
      abstract     = {The liver is the sixth most common site of primary cancer
                      in humans, and generally arises in a background of cirrhosis
                      and inflammation. Moreover, the liver is frequently
                      colonized by metastases from cancers of other organs
                      (particularly the colon) because of its anatomical location
                      and organization, as well as its unique metabolic and
                      immunosuppressive environment. In this Review, we discuss
                      how the hepatic microenvironment adapts to pathologies
                      characterized by chronic inflammation and metabolic
                      alterations. We illustrate how these immunological or
                      metabolic changes alter immunosurveillance and thus hinder
                      or promote the development of primary liver cancer. In
                      addition, we describe how inflammatory and metabolic niches
                      affect the spreading of cancer metastases into or within the
                      liver. Finally, we review the current therapeutic options in
                      this context and the resulting challenges that must be
                      surmounted.},
      subtyp        = {Review Article},
      cin          = {F180 / TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)F180-20160331 / I:(DE-He78)TU01-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34326518},
      doi          = {10.1038/s41568-021-00383-9},
      url          = {https://inrepo02.dkfz.de/record/170064},
}