% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Liermann:170073,
      author       = {J. Liermann$^*$ and P. Naumann and F. Weykamp and P.
                      Hoegen$^*$ and J. Debus$^*$ and K. Herfarth$^*$},
      title        = {{E}ffectiveness of {C}arbon {I}on {R}adiation in {L}ocally
                      {A}dvanced {P}ancreatic {C}ancer.},
      journal      = {Frontiers in oncology},
      volume       = {11},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2021-01739},
      pages        = {708884},
      year         = {2021},
      abstract     = {Effective treatment strategies for unresectable locally
                      advanced pancreatic cancer (LAPC) patients are eagerly
                      warranted. Recently, convincing oncological outcomes were
                      demonstrated by carbon ion radiotherapy. Nevertheless, there
                      is a lack of evidence for this modern radiation technique
                      due to the limited number of carbon ion facilities
                      worldwide. Here, we analyze feasibility and efficacy of
                      carbon ion radiotherapy in the management of LAPC at
                      Heidelberg Ion Beam Therapy Center (HIT).Between 2015 and
                      2020, 21 LAPC patients were irradiated with carbon ions with
                      a total dose of 48 Gy (RBE) in single doses of 4 Gy (RBE).
                      Three patients $(14\%)$ were treated with concomitant
                      chemotherapy with gemcitabine 300 mg/m2 body surface weekly.
                      Toxicity rates were extracted from the charts. Overall
                      survival, progression free survival, local control, and
                      locoregional control were evaluated using Kaplan-Meier
                      estimates.One patient developed ascites CTCAE grade III
                      during radiotherapy, which was related to a later
                      histologically confirmed metachronous peritoneal
                      carcinomatosis. No further higher-graded toxicity could be
                      observed. The most common symptoms were nausea and abdominal
                      pain. After a median estimated follow-up time of 19.1
                      months, the median progression free survival was 3.7 months,
                      and the median overall survival was 11.9 months. The
                      estimated 1-year local control and locoregional control
                      rates were 89 and $84\%,$ respectively.Carbon ion
                      radiotherapy of LAPC patients is safely feasible. Local
                      tumor control rates were high. Nevertheless, compared to
                      historical data, an overall survival improvement could not
                      be observed. This could be explained by the poor prognosis
                      of the selected underlying patients that mostly did not
                      respond to prior chemotherapy as well as the early and
                      frequent emergence of distant metastases that demonstrate
                      the necessity of additional chemotherapy in further
                      studies.},
      keywords     = {carbon ion radiotherapy (Other) / heavy ion (Other) /
                      irradiation (Other) / locally advanced pancreatic cancer
                      (Other) / pancreatic cancer (Other) / particle therapy
                      (Other)},
      cin          = {E050 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34336696},
      pmc          = {pmc:PMC8318663},
      doi          = {10.3389/fonc.2021.708884},
      url          = {https://inrepo02.dkfz.de/record/170073},
}