TY  - JOUR
AU  - Rücker, Frank G
AU  - Du, Ling
AU  - Luck, Tamara J
AU  - Benner, Axel
AU  - Krzykalla, Julia
AU  - Gathmann, Insa
AU  - Voso, Maria Teresa
AU  - Amadori, Sergio
AU  - Prior, Thomas W
AU  - Brandwein, Joseph M
AU  - Appelbaum, Frederick R
AU  - Medeiros, Bruno C
AU  - Tallman, Martin S
AU  - Savoie, Lynn
AU  - Sierra, Jorge
AU  - Pallaud, Celine
AU  - Sanz, Miguel A
AU  - Jansen, Joop H
AU  - Niederwieser, Dietger
AU  - Fischer, Thomas
AU  - Ehninger, Gerhard
AU  - Heuser, Michael
AU  - Ganser, Arnold
AU  - Bullinger, Lars
AU  - Larson, Richard A
AU  - Bloomfield, Clara D
AU  - Stone, Richard M
AU  - Döhner, Hartmut
AU  - Thiede, Christian
AU  - Döhner, Konstanze
TI  - Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
JO  - Leukemia
VL  - 36
IS  - 1
SN  - 1476-5551
CY  - London
PB  - Springer Nature
M1  - DKFZ-2021-01743
SP  - 90-99
PY  - 2022
N1  - 2022 Jan;36(1):90-99
AB  - In acute myeloid leukemia (AML) internal tandem duplications of the FLT3 gene (FLT3-ITD) are associated with poor prognosis. Retrospectively, we investigated the prognostic and predictive impact of FLT3-ITD insertion site (IS) in 452 patients randomized within the RATIFY trial, which evaluated midostaurin additionally to intensive chemotherapy. Next-generation sequencing identified 908 ITDs, with 643 IS in the juxtamembrane domain (JMD) and 265 IS in the tyrosine kinase domain-1 (TKD1). According to IS, patients were categorized as JMDsole (n = 251, 55
LB  - PUB:(DE-HGF)16
C6  - pmid:34316017
DO  - DOI:10.1038/s41375-021-01323-0
UR  - https://inrepo02.dkfz.de/record/170080
ER  -