000170084 001__ 170084
000170084 005__ 20240229133705.0
000170084 0247_ $$2doi$$a10.1007/s00066-021-01816-y
000170084 0247_ $$2pmid$$apmid:34342662
000170084 0247_ $$2ISSN$$a0179-7158
000170084 0247_ $$2ISSN$$a1439-099X
000170084 0247_ $$2altmetric$$aaltmetric:112758881
000170084 037__ $$aDKFZ-2021-01747
000170084 041__ $$aEnglish
000170084 082__ $$a610
000170084 1001_ $$0P:(DE-He78)80e100a16534f5fc67f7436ee67a47f9$$aRühle, Alexander$$b0$$eFirst author$$udkfz
000170084 245__ $$aLow-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites.
000170084 260__ $$aHeidelberg$$bSpringer Medizin$$c2021
000170084 3367_ $$2DRIVER$$aarticle
000170084 3367_ $$2DataCite$$aOutput Types/Journal article
000170084 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1642410955_11680
000170084 3367_ $$2BibTeX$$aARTICLE
000170084 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000170084 3367_ $$00$$2EndNote$$aJournal Article
000170084 500__ $$a#EA:E055#LA:E055# / 2021 Oct;197(10):895-902
000170084 520__ $$aPainful osteoarthritis is common in elderly patients, and low-dose radiotherapy has been demonstrated to provide effective symptomatic treatment. We examined the analgesic effects of low-dose radiotherapy for osteoarthritis in the elderly aiming to reveal potential differences in the response rates relating to increasing age.A retrospective analysis was performed at two university hospitals including elderly patients (≥ 65 years) undergoing radiotherapy for osteoarthritis between 2008 and 2020. Pain intensity and response were quantified using the numerical rating scale (NRS) and the Pannewitz score. Age groups were defined for young old (65-74 years), older old (75-84 years), and oldest old patients (≥ 85 years).In all, 970 patients with 1185 treated sites and a median age of 76 years were analyzed. Mean NRS was 66 at baseline (t0), 53 after radiotherapy (t1), and 44 at first follow-up (t2) (p < 0.001 for t0-t1, t1-t2, and t0-t2). At t1, 1.5% exhibited a Pannewitz score of 0 (no pain), 58.5% of 1-2 (less pain), 36.1% of 3 (equal pain), and 3.9% of 4 (worse pain), while at t2, pain response shifted towards 6.9% (0), 58.6% (1-2), 28.1% (3), and 6.3% (4). Pain response did not differ between age groups at t1 (p = 0.172) or t2 (p = 0.684). In addition, pain response after re-irradiation (n = 384 sites) was 61.0% and was comparable between age groups (p = 0.535).Low-dose radiotherapy results in pain reduction in about two-thirds of treated sites with no difference relating to increasing age, showing that radiotherapy is an effective analgesic treatment for osteoarthritis even at advanced ages.
000170084 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000170084 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000170084 650_7 $$2Other$$aBenign diseases
000170084 650_7 $$2Other$$aElderly patients
000170084 650_7 $$2Other$$aJoint disorder
000170084 650_7 $$2Other$$aLow-dose radiotherapy
000170084 650_7 $$2Other$$aOsteoarthritis
000170084 7001_ $$aTkotsch, Elisabeth$$b1
000170084 7001_ $$aMravlag, Rainer$$b2
000170084 7001_ $$0P:(DE-HGF)0$$aHaehl, Erik$$b3
000170084 7001_ $$0P:(DE-HGF)0$$aSpohn, Simon K B$$b4
000170084 7001_ $$0P:(DE-HGF)0$$aZamboglou, Constantinos$$b5
000170084 7001_ $$0P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aHuber, Peter E$$b6$$udkfz
000170084 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b7$$udkfz
000170084 7001_ $$0P:(DE-HGF)0$$aGrosu, Anca-Ligia$$b8
000170084 7001_ $$0P:(DE-HGF)0$$aSprave, Tanja$$b9
000170084 7001_ $$0P:(DE-He78)8d52e7ff1ccaac7dbf0232fdcb0168bd$$aNicolay, Nils$$b10$$eLast author$$udkfz
000170084 773__ $$0PERI:(DE-600)2003907-4$$a10.1007/s00066-021-01816-y$$n10$$p895-902$$tStrahlentherapie und Onkologie$$v197$$x1439-099X$$y2021
000170084 909CO $$ooai:inrepo02.dkfz.de:170084$$pVDB
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)80e100a16534f5fc67f7436ee67a47f9$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000170084 9101_ $$0I:(DE-HGF)0$$6P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aExternal Institute$$b7$$kExtern
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000170084 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8d52e7ff1ccaac7dbf0232fdcb0168bd$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000170084 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000170084 9141_ $$y2021
000170084 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-26$$wger
000170084 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2021-01-26$$wger
000170084 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSTRAHLENTHER ONKOL : 2019$$d2021-01-26
000170084 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-01-26
000170084 9201_ $$0I:(DE-He78)FR01-20160331$$kFR01$$lDKTK FR zentral$$x0
000170084 9201_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Translationale Radioonkologie$$x1
000170084 980__ $$ajournal
000170084 980__ $$aVDB
000170084 980__ $$aI:(DE-He78)FR01-20160331
000170084 980__ $$aI:(DE-He78)E055-20160331
000170084 980__ $$aUNRESTRICTED