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@ARTICLE{Rhle:170084,
      author       = {A. Rühle$^*$ and E. Tkotsch and R. Mravlag and E.
                      Haehl$^*$ and S. K. B. Spohn$^*$ and C. Zamboglou$^*$ and P.
                      E. Huber$^*$ and J. Debus and A.-L. Grosu$^*$ and T.
                      Sprave$^*$ and N. Nicolay$^*$},
      title        = {{L}ow-dose radiotherapy for painful osteoarthritis of the
                      elderly: {A} multicenter analysis of 970 patients with
                      1185 treated sites.},
      journal      = {Strahlentherapie und Onkologie},
      volume       = {197},
      number       = {10},
      issn         = {1439-099X},
      address      = {Heidelberg},
      publisher    = {Springer Medizin},
      reportid     = {DKFZ-2021-01747},
      pages        = {895-902},
      year         = {2021},
      note         = {#EA:E055#LA:E055# / 2021 Oct;197(10):895-902},
      abstract     = {Painful osteoarthritis is common in elderly patients, and
                      low-dose radiotherapy has been demonstrated to provide
                      effective symptomatic treatment. We examined the analgesic
                      effects of low-dose radiotherapy for osteoarthritis in the
                      elderly aiming to reveal potential differences in the
                      response rates relating to increasing age.A retrospective
                      analysis was performed at two university hospitals including
                      elderly patients (≥ 65 years) undergoing radiotherapy for
                      osteoarthritis between 2008 and 2020. Pain intensity and
                      response were quantified using the numerical rating scale
                      (NRS) and the Pannewitz score. Age groups were defined for
                      young old (65-74 years), older old (75-84 years), and
                      oldest old patients (≥ 85 years).In all, 970 patients
                      with 1185 treated sites and a median age of 76 years were
                      analyzed. Mean NRS was 66 at baseline (t0), 53 after
                      radiotherapy (t1), and 44 at first follow-up (t2) (p < 0.001
                      for t0-t1, t1-t2, and t0-t2). At t1, $1.5\%$ exhibited
                      a Pannewitz score of 0 (no pain), $58.5\%$ of 1-2 (less
                      pain), $36.1\%$ of 3 (equal pain), and $3.9\%$ of 4 (worse
                      pain), while at t2, pain response shifted towards $6.9\%$
                      (0), $58.6\%$ (1-2), $28.1\%$ (3), and $6.3\%$ (4). Pain
                      response did not differ between age groups at t1 (p = 0.172)
                      or t2 (p = 0.684). In addition, pain response after
                      re-irradiation (n = 384 sites) was $61.0\%$ and was
                      comparable between age groups (p = 0.535).Low-dose
                      radiotherapy results in pain reduction in about two-thirds
                      of treated sites with no difference relating to increasing
                      age, showing that radiotherapy is an effective analgesic
                      treatment for osteoarthritis even at advanced ages.},
      keywords     = {Benign diseases (Other) / Elderly patients (Other) / Joint
                      disorder (Other) / Low-dose radiotherapy (Other) /
                      Osteoarthritis (Other)},
      cin          = {FR01 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34342662},
      doi          = {10.1007/s00066-021-01816-y},
      url          = {https://inrepo02.dkfz.de/record/170084},
}