%0 Journal Article
%A Miller, Anna K
%A Tavera, Gloria
%A Dominguez, Ricardo L
%A Camargo, M Constanza
%A Waterboer, Tim
%A Wilson, Keith T
%A Williams, Scott M
%A Morgan, Douglas R
%T Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus.
%J Oncogene
%V 40
%N 40
%@ 1476-5594
%C London
%I Springer Nature
%M DKFZ-2021-01816
%P 5963-5969
%D 2021
%Z 2021 Oct;40(40):5963-5969
%X The primary cause of gastric cancer is chronic infection with Helicobacter pylori (H. pylori), particularly the high-risk genotype cagA, and risk modification by human genetic variants. We studied 94 variants in 54 genes for association with gastric cancer, including rs2302615 in ornithine decarboxylase (ODC1), which may affect response to chemoprevention with the ODC inhibitor, eflornithine (difluoromethylornithine; DFMO). Our population-based, case-control study included 1366 individuals (664 gastric cancer cases and 702 controls) from Western Honduras, a high incidence region of Latin America. CagA seropositivity was strongly associated with cancer (OR = 3.6; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34376808
%R 10.1038/s41388-021-01981-5
%U https://inrepo02.dkfz.de/record/170193