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@ARTICLE{Miller:170193,
      author       = {A. K. Miller and G. Tavera and R. L. Dominguez and M. C.
                      Camargo and T. Waterboer$^*$ and K. T. Wilson and S. M.
                      Williams and D. R. Morgan},
      title        = {{O}rnithine decarboxylase ({ODC}1) gene variant (rs2302615)
                      is associated with gastric cancer independently of
                      {H}elicobacter pylori {C}ag{A} serostatus.},
      journal      = {Oncogene},
      volume       = {40},
      number       = {40},
      issn         = {1476-5594},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2021-01816},
      pages        = {5963-5969},
      year         = {2021},
      note         = {2021 Oct;40(40):5963-5969},
      abstract     = {The primary cause of gastric cancer is chronic infection
                      with Helicobacter pylori (H. pylori), particularly the
                      high-risk genotype cagA, and risk modification by human
                      genetic variants. We studied 94 variants in 54 genes for
                      association with gastric cancer, including rs2302615 in
                      ornithine decarboxylase (ODC1), which may affect response to
                      chemoprevention with the ODC inhibitor, eflornithine
                      (difluoromethylornithine; DFMO). Our population-based,
                      case-control study included 1366 individuals (664 gastric
                      cancer cases and 702 controls) from Western Honduras, a high
                      incidence region of Latin America. CagA seropositivity was
                      strongly associated with cancer (OR = 3.6; $95\%$ CI: 2.6,
                      5.1). The ODC1 variant rs2302615 was associated with gastric
                      cancer (OR = 1.36; p = 0.018) in a model adjusted for age,
                      sex, and CagA serostatus. Two additional single nucleotide
                      polymorphisms (SNPs) in CASP1 (rs530537) and TLR4
                      (rs1927914) genes were also associated with gastric cancer
                      in univariate models as well as models adjusted for age,
                      sex, and CagA serostatus. The ODC1 SNP association with
                      gastric cancer was stronger in individuals who carried the
                      TT genotype at the associating TLR4 polymorphism, rs1927914
                      (OR = 1.77; p = 1.85 × 10-3). In conclusion, the ODC1
                      variant, rs2302615, is associated with gastric cancer and
                      supports chemoprevention trials with DFMO, particularly in
                      individuals homozygous for the T allele at rs1927914.},
      cin          = {F022 / F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34376808},
      doi          = {10.1038/s41388-021-01981-5},
      url          = {https://inrepo02.dkfz.de/record/170193},
}