TY  - JOUR
AU  - Weber, Marc-André
AU  - Seyler, Lisa
AU  - Nagel, Armin
TI  - 7 Tesla Chlor (35Cl) und Natrium (23Na) MR-Bildgebung eines Enchondroms.
JO  - RöFo
VL  - 193
IS  - 10
SN  - 1438-9010
CY  - Stuttgart [u.a.]
PB  - Thieme
M1  - DKFZ-2021-01837
SP  - 1207-1211
PY  - 2021
N1  - #LA:E020# / 2021 Oct;193(10):1207-1211
AB  - We demonstrated the feasibility of 7 Tesla sodium (23Na) and chlorine (35Cl) MRI of a solitary enchondroma. For this, we established dedicated sequences on a 7-Tesla whole-body system with the following key parameters for 35Cl MRI: TE/TR = 0.35/60 ms, TRO = 5 ms, α = 90°, Δx3 = (6 mm)3, 3 averages, Tacq = 30 min and for 23Na MRI: TE/TR = 0.4/101 ms, TRO = 10ms; α = 90°; Δx3 = (1.9 mm)3, 3 averages, Tacq = 30 min 18 s. The measured apparent Na+ concentration was 255 mmol/l and was approximately 7-fold higher than the apparent Cl- concentration with about 36 mmol/l. Additionally, repeated proton MRI examinations demonstrated constant but subtle growth (≈ 0.65 ml/year) over 14 years. In conclusion, enchondromas obviously have a high contrast-to-noise ratio when compared with the normal bone marrow in 23Na and 35Cl MRI, which may contribute to detection and differentiation in unclear or subtle cases. KEY POINTS:: · High magnetic field strengths (e. g., 7 Tesla) enable sodium (23Na) and chlorine (35Cl) MRI of solitary cartilage-forming tumors like enchondromas with nominal spatial resolutions of (1.9 mm)3 (23Na MRI) and (6 mm)3 (35Cl MRI).. · Measured median tumoral apparent Na+ and Cl- concentrations were nearly 13 times higher and 3 times higher than in normal muscle tissue, respectively.. · Enchondromas have a high contrast-to-noise-ratio when compared with the normal bone marrow in 23Na and 35Cl MRI, which may contribute to detection and differentiation in unclear or subtle cases.. CITATION FORMAT: · Weber M, Seyler L, Nagel AM. 7 Tesla Chlorine (35Cl) and Sodium (23Na) MR Imaging of an Enchondroma. Fortschr Röntgenstr 2021; DOI: 10.1055/a-1472-6730.
LB  - PUB:(DE-HGF)16
C6  - pmid:34384113
DO  - DOI:10.1055/a-1472-6730
UR  - https://inrepo02.dkfz.de/record/170229
ER  -