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@ARTICLE{Weber:170229,
      author       = {M.-A. Weber and L. Seyler and A. Nagel$^*$},
      title        = {7 {T}esla {C}hlor (35{C}l) und {N}atrium (23{N}a)
                      {MR}-{B}ildgebung eines {E}nchondroms.},
      journal      = {RöFo},
      volume       = {193},
      number       = {10},
      issn         = {1438-9010},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme},
      reportid     = {DKFZ-2021-01837},
      pages        = {1207-1211},
      year         = {2021},
      note         = {#LA:E020# / 2021 Oct;193(10):1207-1211},
      abstract     = {We demonstrated the feasibility of 7 Tesla sodium (23Na)
                      and chlorine (35Cl) MRI of a solitary enchondroma. For this,
                      we established dedicated sequences on a 7-Tesla whole-body
                      system with the following key parameters for 35Cl MRI: TE/TR
                      = 0.35/60 ms, TRO = 5 ms, α = 90°, Δx3 = (6 mm)3,
                      3 averages, Tacq = 30 min and for 23Na MRI: TE/TR = 0.4/101
                      ms, TRO = 10ms; α = 90°; Δx3 = (1.9 mm)3, 3 averages,
                      Tacq = 30 min 18 s. The measured apparent Na+ concentration
                      was 255 mmol/l and was approximately 7-fold higher than the
                      apparent Cl- concentration with about 36 mmol/l.
                      Additionally, repeated proton MRI examinations demonstrated
                      constant but subtle growth (≈ 0.65 ml/year) over 14
                      years. In conclusion, enchondromas obviously have a high
                      contrast-to-noise ratio when compared with the normal bone
                      marrow in 23Na and 35Cl MRI, which may contribute to
                      detection and differentiation in unclear or subtle cases.
                      KEY POINTS:: · High magnetic field strengths (e. g., 7
                      Tesla) enable sodium (23Na) and chlorine (35Cl) MRI of
                      solitary cartilage-forming tumors like enchondromas with
                      nominal spatial resolutions of (1.9 mm)3 (23Na MRI) and (6
                      mm)3 (35Cl MRI).. · Measured median tumoral apparent Na+
                      and Cl- concentrations were nearly 13 times higher and 3
                      times higher than in normal muscle tissue, respectively.. ·
                      Enchondromas have a high contrast-to-noise-ratio when
                      compared with the normal bone marrow in 23Na and 35Cl MRI,
                      which may contribute to detection and differentiation in
                      unclear or subtle cases.. CITATION FORMAT: · Weber M,
                      Seyler L, Nagel AM. 7 Tesla Chlorine (35Cl) and Sodium
                      (23Na) MR Imaging of an Enchondroma. Fortschr Röntgenstr
                      2021; DOI: 10.1055/a-1472-6730.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34384113},
      doi          = {10.1055/a-1472-6730},
      url          = {https://inrepo02.dkfz.de/record/170229},
}