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@ARTICLE{Aigner:170243,
      author       = {C. S. Aigner and S. Dietrich and T. Schaeffter and S.
                      Schmitter$^*$},
      title        = {{C}alibration-free p{T}x of the human heart at 7{T} via
                      3{D} universal pulses.},
      journal      = {Magnetic resonance in medicine},
      volume       = {87},
      number       = {1},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-01851},
      pages        = {70-84},
      year         = {2022},
      note         = {#LA:E020# / 2022 Jan;87(1):70-84},
      abstract     = {MRI at ultra-high fields in the human body is highly
                      challenging and requires lengthy calibration times to
                      compensate for spatially heterogeneous B 1 + profiles. This
                      study investigates the feasibility of using pre-computed
                      universal pulses for calibration-free homogeneous 3D flip
                      angle distribution in the human heart at 7T.Twenty-two
                      channel-wise 3D B 1 + data sets were acquired under
                      free-breathing in 19 subjects to generate a library for an
                      offline universal pulse (UP) design (group 1: 12 males [M]
                      and 7 females [F], 21-66 years, 19.8-28.3 kg/m2 ). Three of
                      these subjects (2M/1F, 21-33 years, 20.8-23.6 kg/m2 ) were
                      re-scanned on different days. A 4kT-points UP optimized for
                      the 22 channel-wise 3D B 1 + data sets in group 1 (UP22-4kT)
                      is proposed and applied at 7T in 9 new and unseen subjects
                      (group 2: 4M/5F, 25-56 years, 19.5-35.3 kg/m2 ). Multiple
                      tailored and universal static and dynamic parallel-transmit
                      (pTx) pulses were designed and evaluated for different
                      permutations of the B 1 + data sets in group 1 and 2.The
                      proposed UP22-4kT provides low B 1 + variation in all
                      subjects, seen and unseen, without severe signal drops.
                      Experimental data at 7T acquired with UP22-4kT shows
                      comparable image quality as data acquired with tailored-4kT
                      pulses and demonstrates successful calibration-free pTx of
                      the human heart.UP22-4kT allows for calibration-free
                      homogeneous flip angle distributions across the human heart
                      at 7T. Large inter-subject variations because of sex, age,
                      and body mass index are well tolerated. The proposed
                      universal pulse removes the need for lengthy (10-15 min)
                      calibration scans and therefore has the potential to bring
                      body imaging at 7T closer to the clinical application.},
      keywords     = {7 Tesla (Other) / body MRI (Other) / heart (Other) /
                      parallel transmission (Other) / universal pulse (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34399002},
      doi          = {10.1002/mrm.28952},
      url          = {https://inrepo02.dkfz.de/record/170243},
}