TY  - JOUR
AU  - Coltin, Hallie
AU  - Sundaresan, Lakshmikirupa
AU  - Smith, Kyle S
AU  - Skowron, Patryk
AU  - Massimi, Luca
AU  - Eberhart, Charles G
AU  - Schreck, Karisa C
AU  - Gupta, Nalin
AU  - Weiss, William A
AU  - Tirapelli, Daniela
AU  - Carlotti, Carlos
AU  - Li, Kay K W
AU  - Ryzhova, Marina
AU  - Golanov, Andrey
AU  - Zheludkova, Olga
AU  - Absalyamova, Oksana
AU  - Okonechnikov, Konstantin
AU  - Stichel, Damian
AU  - von Deimling, Andreas
AU  - Giannini, Caterina
AU  - Raskin, Scott
AU  - Van Meir, Erwin G
AU  - Chan, Jennifer A
AU  - Fults, Daniel
AU  - Chambless, Lola B
AU  - Kim, Seung-Ki
AU  - Vasiljevic, Alexandre
AU  - Faure-Conter, Cecile
AU  - Vibhakar, Rajeev
AU  - Jung, Shin
AU  - Leary, Sarah
AU  - Mora, Jaume
AU  - McLendon, Roger E
AU  - Pollack, Ian F
AU  - Hauser, Peter
AU  - Grajkowska, Wieslawa A
AU  - Rubin, Joshua B
AU  - van Veelen, Marie-Lise C
AU  - French, Pim J
AU  - Kros, Johan M
AU  - Liau, Linda M
AU  - Pfister, Stefan M
AU  - Kool, Marcel
AU  - Kijima, Noriyuki
AU  - Taylor, Michael D
AU  - Packer, Roger J
AU  - Northcott, Paul A
AU  - Korshunov, Andrey
AU  - Ramaswamy, Vijay
TI  - Subgroup and subtype-specific outcomes in adult medulloblastoma.
JO  - Acta neuropathologica
VL  - 142
IS  - 5
SN  - 1432-0533
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2021-01895
SP  - 859-871
PY  - 2021
N1  - #LA:B300# / 2021 Nov;142(5):859-871
AB  - Medulloblastoma, a common pediatric malignant central nervous system tumour, represent a small proportion of brain tumours in adults. Previously it has been shown that in adults, Sonic Hedgehog (SHH)-activated tumours predominate, with Wingless-type (WNT) and Group 4 being less common, but molecular risk stratification remains a challenge. We performed an integrated analysis consisting of genome-wide methylation profiling, copy number profiling, somatic nucleotide variants and correlation of clinical variables across a cohort of 191 adult medulloblastoma cases identified through the Medulloblastoma Advanced Genomics International Consortium. We identified 30 WNT, 112 SHH, 6 Group 3, and 41 Group 4 tumours. Patients with SHH tumours were significantly older at diagnosis compared to other subgroups (p < 0.0001). Five-year progression-free survival (PFS) for WNT, SHH, Group 3, and Group 4 tumours was 64.4 (48.0-86.5), 61.9
KW  - Adult (Other)
KW  - DNA methylation profiling (Other)
KW  - Medulloblastoma (Other)
KW  - Molecular groups (Other)
KW  - Risk stratification (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34409497
DO  - DOI:10.1007/s00401-021-02358-4
UR  - https://inrepo02.dkfz.de/record/170386
ER  -