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@ARTICLE{Jaensch:170448,
      author       = {A. Jaensch and B. Schöttker$^*$ and R. Schmucker and W.
                      Koenig and H. Brenner$^*$ and D. Rothenbacher$^*$},
      title        = {{P}revalence and {P}rognostic {V}alue of {P}sychological
                      {S}tress {E}vents in {P}atients with {F}irst {M}yocardial
                      {I}nfarction-{L}ong-{T}erm {F}ollow-{U}p {S}tudy.},
      journal      = {Journal of Clinical Medicine},
      volume       = {10},
      number       = {16},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-01941},
      pages        = {3562},
      year         = {2021},
      note         = {#LA:C070#},
      abstract     = {While there is good evidence that symptoms of depression
                      determine prognosis of patients with coronary heart disease
                      (CHD), the role of psychological stress is less clear. We
                      evaluated the prognostic value of stressful events in
                      patients with initial myocardial infarction (MI) with
                      respect to subsequent cardiovascular events. The
                      KAROLA-study included patients with CHD who participated in
                      an in-patient rehabilitation program. A total of 577
                      patients with initial MI were included and self-reported
                      psychological stressful events before their MI was assessed
                      by a structured questionnaire. Hazard ratios were used to
                      evaluate the long-term association of stressful events with
                      secondary cardiovascular events. Additionally, associations
                      of stressful events with depression, anxiety and other
                      cardiovascular risk factors were investigated. Unusual
                      stress at work $(26.5\%)$ and sleep disorder $(23.4\%)$ were
                      the most frequently reported stressful events that occurred
                      in the last 4 weeks before MI. However, only death of a
                      family member showed a statistically significant increase in
                      risk for subsequent cardiovascular events (HR: 1.59;
                      $95\%-CI:$ 1.01-2.50) and this result was not corrected for
                      multiple testing. Notably, we found higher symptom scores of
                      anxiety and depression associated with all single stressful
                      event items. In conclusion, we found no clear patterns that
                      psychological stressful events before MI would increase the
                      long-term risk of subsequent adverse CHD events directly.
                      However, we saw increased symptom scores of anxiety and
                      depression in persons with stressful events.},
      keywords     = {anxiety (Other) / coronary heart disease (Other) /
                      depression (Other) / myocardial infarction (Other) /
                      psychological stress events (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34441858},
      pmc          = {pmc:PMC8397004},
      doi          = {10.3390/jcm10163562},
      url          = {https://inrepo02.dkfz.de/record/170448},
}