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@ARTICLE{Londoo:170450,
      author       = {C. Londoño and V. Cayssials and I. de Villasante and M.
                      Crous-Bou and A. Scalbert and E. Weiderpass and A. Agudo and
                      A. Tjønneland and A. Olsen and K. Overvad and V. Katzke$^*$
                      and M. Schulze and D. Palli and V. Krogh and M. Santucci de
                      Magistris and R. Tumino and F. Ricceri and I. T. Gram and C.
                      Rylander and G. Skeie and M.-J. Sánchez and P. Amiano and
                      J. M. Huerta and A. Barricarte and H. Sartor and E.
                      Sonestedt and A. Esberg and A. Idahl and Y. Mahamat-Saleh
                      and N. Laouali and M. Kvaskoff and R. Turzanski-Fortner$^*$
                      and R. Zamora-Ros},
      title        = {{P}olyphenol {I}ntake and {E}pithelial {O}varian {C}ancer
                      {R}isk in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}) {S}tudy.},
      journal      = {Antioxidants},
      volume       = {10},
      number       = {8},
      issn         = {2076-3921},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-01943},
      pages        = {1249},
      year         = {2021},
      abstract     = {Despite some epidemiological evidence on the protective
                      effects of polyphenol intake on epithelial ovarian cancer
                      (EOC) risk from case-control studies, the evidence is scarce
                      from prospective studies and non-existent for several
                      polyphenol classes. Therefore, we aimed to investigate the
                      associations between the intake of total, classes and
                      subclasses of polyphenols and EOC risk in a large
                      prospective study. The study was conducted in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort, which included 309,129 adult women recruited mostly
                      from the general population. Polyphenol intake was assessed
                      through validated country-specific dietary questionnaires
                      and the Phenol-Explorer database. During a mean follow-up of
                      14 years, 1469 first incident EOC cases (including 806
                      serous, 129 endometrioid, 102 mucinous, and 67 clear cell
                      tumours) were identified. In multivariable-adjusted Cox
                      regression models, the hazard ratio in the highest quartile
                      of total polyphenol intake compared with the lowest quartile
                      (HRQ4vsQ1) was 1.14 $(95\%$ CI 0.94-1.39; p-trend = 0.11).
                      Similarly, the intake of most classes and subclasses of
                      polyphenols were not related to either overall EOC risk or
                      any EOC subtype. A borderline statistically significant
                      positive association was observed between phenolic acid
                      intake (HRQ4vsQ1 = 1.20, $95\%$ CI 1.01-1.43; p-trend =
                      0.02) and EOC risk, especially for the serous subtype and in
                      women with obesity, although these associations did not
                      exceed the Bonferroni correction threshold. The current
                      results do not support any association between polyphenol
                      intake and EOC in our large European prospective study.
                      Results regarding phenolic acid intake need further
                      investigation.},
      keywords     = {EPIC (Other) / cohort (Other) / flavonoids (Other) / intake
                      (Other) / ovarian cancer (Other) / polyphenols (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34439497},
      pmc          = {pmc:PMC8389235},
      doi          = {10.3390/antiox10081249},
      url          = {https://inrepo02.dkfz.de/record/170450},
}