TY  - JOUR
AU  - Li, Xinjun
AU  - Koskinen, Anni I
AU  - Hemminki, Otto
AU  - Försti, Asta
AU  - Sundquist, Jan
AU  - Sundquist, Kristina
AU  - Hemminki, Kari
TI  - Family History of Head and Neck Cancers.
JO  - Cancers
VL  - 13
IS  - 16
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-01947
SP  - 4115
PY  - 2021
AB  - Head and neck cancers (HNCs) encompass a heterogeneous group of cancers between the mouth and larynx. Familial clustering in HNCs has been described, but how it influences individual sites and to which extent known risk factors, such as human papilloma virus (HPV) infection, may contribute is not well established.We employed standardized incidence ratios (SIRs) to estimate familial risks for HNC with same (concordant) and different (discordant) cancers among first-degree relatives using data from the Swedish Cancer Registry from 1958 to 2018.Incidence for male and female oropharyngeal cancer increased close to four-fold in the past 39 years. Familial HNC was found in 3.4
KW  - genetic factors (Other)
KW  - human papilloma virus (Other)
KW  - oral cancer (Other)
KW  - pharyngeal cancer (Other)
KW  - smoking (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34439270
C2  - pmc:PMC8392405
DO  - DOI:10.3390/cancers13164115
UR  - https://inrepo02.dkfz.de/record/170454
ER  -