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@ARTICLE{Li:170454,
      author       = {X. Li and A. I. Koskinen and O. Hemminki and A. Försti$^*$
                      and J. Sundquist and K. Sundquist and K. Hemminki$^*$},
      title        = {{F}amily {H}istory of {H}ead and {N}eck {C}ancers.},
      journal      = {Cancers},
      volume       = {13},
      number       = {16},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-01947},
      pages        = {4115},
      year         = {2021},
      abstract     = {Head and neck cancers (HNCs) encompass a heterogeneous
                      group of cancers between the mouth and larynx. Familial
                      clustering in HNCs has been described, but how it influences
                      individual sites and to which extent known risk factors,
                      such as human papilloma virus (HPV) infection, may
                      contribute is not well established.We employed standardized
                      incidence ratios (SIRs) to estimate familial risks for HNC
                      with same (concordant) and different (discordant) cancers
                      among first-degree relatives using data from the Swedish
                      Cancer Registry from 1958 to 2018.Incidence for male and
                      female oropharyngeal cancer increased close to four-fold in
                      the past 39 years. Familial HNC was found in $3.4\%$ of the
                      study population, with an overall familial SIR of 1.78.
                      Patients with concordant nasopharyngeal cancer showed a high
                      risk of 23.97, followed by hypopharyngeal cancer (5.43). The
                      husbands of wives with cervical cancer had an increased risk
                      of oropharyngeal cancer.Nasopharyngeal cancers lacked
                      associations with lifestyle or HPV associated cancers,
                      suggesting a role for germline genetics, which was also true
                      for the high-risk families of three HNC patients. In the
                      Swedish population with low smoking levels, HPV is becoming
                      a dominant risk factor, emphasizing the need for sexual
                      hygiene and HPV vaccination.},
      keywords     = {genetic factors (Other) / human papilloma virus (Other) /
                      oral cancer (Other) / pharyngeal cancer (Other) / smoking
                      (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34439270},
      pmc          = {pmc:PMC8392405},
      doi          = {10.3390/cancers13164115},
      url          = {https://inrepo02.dkfz.de/record/170454},
}