TY  - JOUR
AU  - Möllers, Tobias
AU  - Stocker, Hannah
AU  - Perna, Laura
AU  - Nabers, Andreas
AU  - Rujescu, Dan
AU  - Hartmann, Annette M
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Gerwert, Klaus
AU  - Brenner, Hermann
TI  - Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood.
JO  - Alzheimer's research & therapy
VL  - 13
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DKFZ-2021-01965
SP  - 145
PY  - 2021
N1  - #EA:C070#LA:C070#
AB  - To understand the potential for early intervention and prevention measures in Alzheimer's disease, the association between risk factors and early pathological change needs to be assessed. Hence, the aim of this study was to determine whether risk factors of Alzheimer's clinical syndrome (clinical AD), such as body mass index (BMI), are associated with Aβ misfolding in blood, a strong risk marker for AD among older adults.Information on risk factors and blood samples were collected at baseline in the ESTHER study, a population-based cohort study of older adults (age 50-75 years) in Germany. Aβ misfolding in blood plasma was analyzed using an immuno-infrared-sensor in a total of 872 participants in a nested case-control design among incident dementia cases and matched controls. Associations between risk factors and Aβ misfolding were assessed by multiple logistic regression. For comparison, the association between the risk factors and AD incidence during 17 years of follow-up was investigated in parallel among 5987 cohort participants.An inverse association with Aβ misfolding was seen for BMI at age 50 based on reported weight history (aOR 0.64, 95
KW  - Alzheimer’s disease (Other)
KW  - Amyloid beta misfolding (Other)
KW  - BMI (Other)
KW  - cohort study (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34461995
DO  - DOI:10.1186/s13195-021-00889-2
UR  - https://inrepo02.dkfz.de/record/170484
ER  -