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@ARTICLE{Mllers:170484,
      author       = {T. Möllers$^*$ and H. Stocker$^*$ and L. Perna$^*$ and A.
                      Nabers and D. Rujescu and A. M. Hartmann and B. Holleczek
                      and B. Schöttker$^*$ and K. Gerwert and H. Brenner$^*$},
      title        = {{A}β misfolding in blood plasma is inversely associated
                      with body mass index even in middle adulthood.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {13},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2021-01965},
      pages        = {145},
      year         = {2021},
      note         = {#EA:C070#LA:C070#},
      abstract     = {To understand the potential for early intervention and
                      prevention measures in Alzheimer's disease, the association
                      between risk factors and early pathological change needs to
                      be assessed. Hence, the aim of this study was to determine
                      whether risk factors of Alzheimer's clinical syndrome
                      (clinical AD), such as body mass index (BMI), are associated
                      with Aβ misfolding in blood, a strong risk marker for AD
                      among older adults.Information on risk factors and blood
                      samples were collected at baseline in the ESTHER study, a
                      population-based cohort study of older adults (age 50-75
                      years) in Germany. Aβ misfolding in blood plasma was
                      analyzed using an immuno-infrared-sensor in a total of 872
                      participants in a nested case-control design among incident
                      dementia cases and matched controls. Associations between
                      risk factors and Aβ misfolding were assessed by multiple
                      logistic regression. For comparison, the association between
                      the risk factors and AD incidence during 17 years of
                      follow-up was investigated in parallel among 5987 cohort
                      participants.An inverse association with Aβ misfolding was
                      seen for BMI at age 50 based on reported weight history (aOR
                      0.64, $95\%$ CI 0.43-0.96, p = 0.03). Similar but not
                      statistically significant associations were seen for BMI at
                      baseline (i.e., mean age 68) and at age 40. No statistically
                      significant associations with Aβ misfolding were found for
                      other risk factors, such as diabetes, smoking, and physical
                      activity. On the other hand, low physical activity was
                      associated with a significantly reduced risk of developing
                      clinical AD compared to physical inactivity.Our results
                      support that AD pathology may be detectable and associated
                      with reduced weight even in middle adulthood, many years
                      before clinical diagnosis of AD. Physical activity might
                      reduce the risk of onset of AD symptoms.},
      keywords     = {Alzheimer’s disease (Other) / Amyloid beta misfolding
                      (Other) / BMI (Other) / cohort study (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34461995},
      doi          = {10.1186/s13195-021-00889-2},
      url          = {https://inrepo02.dkfz.de/record/170484},
}