000170519 001__ 170519
000170519 005__ 20240229133715.0
000170519 0247_ $$2doi$$a10.1007/s00421-021-04735-z
000170519 0247_ $$2pmid$$apmid:34477931
000170519 0247_ $$2ISSN$$a0020-9376
000170519 0247_ $$2ISSN$$a0301-5548
000170519 0247_ $$2ISSN$$a0365-0863
000170519 0247_ $$2ISSN$$a1432-1025
000170519 0247_ $$2ISSN$$a1439-6319
000170519 0247_ $$2ISSN$$a1439-6327
000170519 0247_ $$2altmetric$$aaltmetric:112840284
000170519 037__ $$aDKFZ-2021-01978
000170519 041__ $$aEnglish
000170519 082__ $$a610
000170519 1001_ $$0P:(DE-He78)7d45057e60dd8002ce648abd6e89da44$$aPal, Anasua$$b0$$eFirst author
000170519 245__ $$aDifferent endurance exercises modulate NK cell cytotoxic and inhibiting receptors.
000170519 260__ $$aHeidelberg$$bSpringer$$c2021
000170519 3367_ $$2DRIVER$$aarticle
000170519 3367_ $$2DataCite$$aOutput Types/Journal article
000170519 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1642423983_11679
000170519 3367_ $$2BibTeX$$aARTICLE
000170519 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000170519 3367_ $$00$$2EndNote$$aJournal Article
000170519 500__ $$a#EA:C110# /2021 Dec;121(12):3379-3387
000170519 520__ $$aInduction of IDO depends on the activation of AhR forming the AhR/IDO axis. Activated AhR can transcribe various target genes including cytotoxic and inhibiting receptors of NK cells. We investigated whether AhR and IDO levels as well as activating (NKG2D) and inhibiting (KIR2DL1) NK cell receptors are influenced by acute exercise and different chronic endurance exercise programs.21 adult breast and prostate cancer patients of the TOP study (NCT02883699) were randomized to intervention programs of 12 weeks of (1) endurance standard training or (2) endurance polarized training after a cardiopulmonary exercise test (CPET). Serum was collected pre-CPET, immediately post-CPET, 1 h post-CPET and after 12 weeks post-intervention. Flow cytometry analysis was performed on autologous serum incubated NK-92 cells for: AhR, IDO, KIR2DL1 and NKG2D. Differences were investigated using analysis-of-variance for acute and analysis-of-covariance for chronic effects.Acute exercise: IDO levels changed over time with a significant increase from post-CPET to 1 h post-CPET (p = 0.03). KIR2DL1 levels significantly decreased over time (p < 0.01). NKG2D levels remained constant (p = 0.31). Chronic exercise: for both IDO and NKG2D a significant group × time interaction, a significant time effect and a significant difference after 12 weeks of intervention were observed (IDO: all p < 0.01, NKG2D: all p > 0.05).Both acute and chronic endurance training may regulate NK cell function via the AhR/IDO axis. This is clinically relevant, as exercise emerges to be a key player in immune regulation.
000170519 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000170519 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000170519 650_7 $$2Other$$aCancer
000170519 650_7 $$2Other$$aExercise
000170519 650_7 $$2Other$$aIDO/TDO
000170519 650_7 $$2Other$$aKynurenine
000170519 650_7 $$2Other$$aNK Cell
000170519 650_7 $$2Other$$aPhysical activity
000170519 650_7 $$2Other$$aTryptophan
000170519 7001_ $$aSchneider, J.$$b1
000170519 7001_ $$aSchlüter, K.$$b2
000170519 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, K.$$b3$$udkfz
000170519 7001_ $$aWiskemann, J.$$b4
000170519 7001_ $$aRosenberger, F.$$b5
000170519 7001_ $$aZimmer, P.$$b6
000170519 773__ $$0PERI:(DE-600)1459054-2$$a10.1007/s00421-021-04735-z$$n12$$p3379-3387$$tEuropean journal of applied physiology$$v121$$x1439-6327$$y2021
000170519 909CO $$ooai:inrepo02.dkfz.de:170519$$pVDB
000170519 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7d45057e60dd8002ce648abd6e89da44$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000170519 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000170519 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000170519 9141_ $$y2021
000170519 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-29$$wger
000170519 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2021-01-29$$wger
000170519 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEUR J APPL PHYSIOL : 2019$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-01-29
000170519 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-01-29
000170519 9201_ $$0I:(DE-He78)C110-20160331$$kC110$$lBewegung, Präventionsforschung und Krebs$$x0
000170519 980__ $$ajournal
000170519 980__ $$aVDB
000170519 980__ $$aI:(DE-He78)C110-20160331
000170519 980__ $$aUNRESTRICTED