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@ARTICLE{Pal:170519,
      author       = {A. Pal$^*$ and J. Schneider and K. Schlüter and K.
                      Steindorf$^*$ and J. Wiskemann and F. Rosenberger and P.
                      Zimmer},
      title        = {{D}ifferent endurance exercises modulate {NK} cell
                      cytotoxic and inhibiting receptors.},
      journal      = {European journal of applied physiology},
      volume       = {121},
      number       = {12},
      issn         = {1439-6327},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-01978},
      pages        = {3379-3387},
      year         = {2021},
      note         = {#EA:C110# /2021 Dec;121(12):3379-3387},
      abstract     = {Induction of IDO depends on the activation of AhR forming
                      the AhR/IDO axis. Activated AhR can transcribe various
                      target genes including cytotoxic and inhibiting receptors of
                      NK cells. We investigated whether AhR and IDO levels as well
                      as activating (NKG2D) and inhibiting (KIR2DL1) NK cell
                      receptors are influenced by acute exercise and different
                      chronic endurance exercise programs.21 adult breast and
                      prostate cancer patients of the TOP study (NCT02883699) were
                      randomized to intervention programs of 12 weeks of (1)
                      endurance standard training or (2) endurance polarized
                      training after a cardiopulmonary exercise test (CPET).
                      Serum was collected pre-CPET, immediately post-CPET, 1 h
                      post-CPET and after 12 weeks post-intervention. Flow
                      cytometry analysis was performed on autologous serum
                      incubated NK-92 cells for: AhR, IDO, KIR2DL1 and NKG2D.
                      Differences were investigated using analysis-of-variance for
                      acute and analysis-of-covariance for chronic effects.Acute
                      exercise: IDO levels changed over time with a significant
                      increase from post-CPET to 1 h post-CPET (p = 0.03).
                      KIR2DL1 levels significantly decreased over time (p < 0.01).
                      NKG2D levels remained constant (p = 0.31). Chronic exercise:
                      for both IDO and NKG2D a significant group × time
                      interaction, a significant time effect and a significant
                      difference after 12 weeks of intervention were observed
                      (IDO: all p < 0.01, NKG2D: all p > 0.05).Both acute and
                      chronic endurance training may regulate NK cell function via
                      the AhR/IDO axis. This is clinically relevant, as exercise
                      emerges to be a key player in immune regulation.},
      keywords     = {Cancer (Other) / Exercise (Other) / IDO/TDO (Other) /
                      Kynurenine (Other) / NK Cell (Other) / Physical activity
                      (Other) / Tryptophan (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34477931},
      doi          = {10.1007/s00421-021-04735-z},
      url          = {https://inrepo02.dkfz.de/record/170519},
}