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000170547 1001_ $$aKirches, Elmar$$b0
000170547 245__ $$aMolecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas.
000170547 260__ $$aHeidelberg$$bSpringer$$c2021
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000170547 500__ $$a2021 Nov;142(5):873-886 
000170547 520__ $$aIn contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors.
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000170547 650_7 $$2Other$$aMeningioma
000170547 650_7 $$2Other$$aMethylation profile
000170547 650_7 $$2Other$$aNF2
000170547 650_7 $$2Other$$aTargeted sequencing
000170547 7001_ $$aSahm, Felix$$b1
000170547 7001_ $$aKorshunov, Andrey$$b2
000170547 7001_ $$aBluecher, Christina$$b3
000170547 7001_ $$aWaldt, Natalie$$b4
000170547 7001_ $$aKropf, Siegfried$$b5
000170547 7001_ $$aSchrimpf, Daniel$$b6
000170547 7001_ $$aSievers, Philipp$$b7
000170547 7001_ $$aStichel, Damian$$b8
000170547 7001_ $$aSchüller, Ulrich$$b9
000170547 7001_ $$aSchittenhelm, Jens$$b10
000170547 7001_ $$aRiemenschneider, Markus J$$b11
000170547 7001_ $$aKarajannis, Matthias A$$b12
000170547 7001_ $$aPerry, Arie$$b13
000170547 7001_ $$aPietsch, Torsten$$b14
000170547 7001_ $$aBoekhoff, Svenja$$b15
000170547 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b16$$udkfz
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000170547 7001_ $$0P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2$$aParamasivam, Nagarajan$$b18$$udkfz
000170547 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b19$$udkfz
000170547 7001_ $$aBrastianos, Priscilla K$$b20
000170547 7001_ $$aMüller, Hermann L$$b21
000170547 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b22$$udkfz
000170547 7001_ $$00000-0002-6677-3124$$aMawrin, Christian$$b23
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