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@ARTICLE{Kirches:170547,
      author       = {E. Kirches and F. Sahm and A. Korshunov and C. Bluecher and
                      N. Waldt and S. Kropf and D. Schrimpf and P. Sievers and D.
                      Stichel and U. Schüller and J. Schittenhelm and M. J.
                      Riemenschneider and M. A. Karajannis and A. Perry and T.
                      Pietsch and S. Boekhoff and D. Capper$^*$ and K. Beck$^*$
                      and N. Paramasivam$^*$ and M. Schlesner$^*$ and P. K.
                      Brastianos and H. L. Müller and S. M. Pfister$^*$ and C.
                      Mawrin},
      title        = {{M}olecular profiling of pediatric meningiomas shows tumor
                      characteristics distinct from adult meningiomas.},
      journal      = {Acta neuropathologica},
      volume       = {142},
      number       = {5},
      issn         = {1432-0533},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-02001},
      pages        = {873-886},
      year         = {2021},
      note         = {2021 Nov;142(5):873-886},
      abstract     = {In contrast to adults, meningiomas are uncommon tumors in
                      childhood and adolescence. Whether adult and pediatric
                      meningiomas differ on a molecular level is unclear. Here we
                      report detailed genomic analyses of 37 pediatric meningiomas
                      by sequencing and DNA methylation profiling. Histologically,
                      the series was dominated by meningioma subtypes with
                      aggressive behavior, with $70\%$ of patients suffering from
                      WHO grade II or III meningiomas. The most frequent
                      cytogenetic aberrations were loss of chromosomes 22 (23/37
                      $[62\%]),$ 1 (9/37 $[24\%]),$ 18 (7/37 $[19\%]),$ and 14
                      (5/37 $[14\%]).$ Tumors with NF2 alterations exhibited
                      overall increased chromosomal instability. Unsupervised
                      clustering of DNA methylation profiles revealed separation
                      into three groups: designated group 1 composed of clear cell
                      and papillary meningiomas, whereas group 2A comprised
                      predominantly atypical meningiomas and group 2B enriched for
                      rare high-grade subtypes (rhabdoid, chordoid). Meningiomas
                      from NF2 patients clustered exclusively within groups 1 and
                      2A. When compared with a dataset of 105 adult meningiomas,
                      the pediatric meningiomas largely grouped separately.
                      Targeted panel DNA sequencing of 34 tumors revealed frequent
                      NF2 alterations, while other typical alterations found in
                      adult non-NF2 tumors were absent. These data demonstrate
                      that pediatric meningiomas are characterized by molecular
                      features distinct from adult tumors.},
      keywords     = {Meningioma (Other) / Methylation profile (Other) / NF2
                      (Other) / Targeted sequencing (Other)},
      cin          = {BE01 / B240 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)B240-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34495383},
      doi          = {10.1007/s00401-021-02351-x},
      url          = {https://inrepo02.dkfz.de/record/170547},
}