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000170556 1001_ $$0P:(DE-He78)62f71d68e658453766d3f349b2b718d4$$aTirinato, Luca$$b0$$eFirst author$$udkfz
000170556 245__ $$aLipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance.
000170556 260__ $$aCambridge$$beLife Sciences Publications$$c2021
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000170556 520__ $$aAlthough much progress has been made in cancer treatment, the molecular mechanisms underlying cancer radioresistance (RR) as well as the biological signatures of radioresistant cancer cells still need to be clarified. In this regard, we discovered that breast, bladder, lung, neuroglioma and prostate 6 Gy X-ray resistant cancer cells were characterized by an increase of Lipid Droplet (LD) number and that the cells containing highest LDs showed the highest clonogenic potential after irradiation. Moreover, we observed that LD content was tightly connected with the iron metabolism and in particular with the presence of the ferritin heavy chain (FTH1). In fact, breast and lung cancer cells silenced for the FTH1 gene showed a reduction in the LD numbers and, by consequence, became radiosensitive. FTH1 overexpression as well as iron-chelating treatment by Deferoxamine were able to restore the LD amount and RR. Overall, these results provide evidence of a novel mechanism behind RR in which LDs and FTH1 are tightly connected to each other, a synergistic effect which might be worth deeply investigating in order to make cancer cells more radiosensitive and improve the efficacy of radiation treatments.
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000170556 650_7 $$2Other$$acancer biology
000170556 650_7 $$2Other$$ahuman
000170556 7001_ $$0P:(DE-He78)7d52a11d422cd6c34bd3001fe0cd3997$$aMarafioti, Maria Grazia$$b1$$eFirst author
000170556 7001_ $$0P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aPagliari, Francesca$$b2$$eFirst author
000170556 7001_ $$0P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade$$aJansen, Jeannette$$b3
000170556 7001_ $$0P:(DE-He78)311c5712bcd4b31083be7845ef5ea377$$aAversa, Ilenia$$b4
000170556 7001_ $$0P:(DE-He78)15d0e694db442a1762a025b802a56f75$$aHanley, Rachel$$b5
000170556 7001_ $$0P:(DE-He78)f9957338cc0970c985bc19ded506b7c1$$aNisticò, Clelia$$b6$$udkfz
000170556 7001_ $$0P:(DE-HGF)0$$aGarcia-Calderón, Daniel$$b7
000170556 7001_ $$0P:(DE-He78)036b60c419272e509b5b5db5246c13bc$$aGenard, Geraldine$$b8
000170556 7001_ $$00000-0003-1960-603X$$aGuerreiro, Joana Filipa$$b9
000170556 7001_ $$aCostanzo, Francesco Saverio$$b10
000170556 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b11$$eLast author
000170556 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.72943$$gVol. 10, p. e72943$$pe72943$$teLife$$v10$$x2050-084X$$y2021
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