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@ARTICLE{Tirinato:170556,
      author       = {L. Tirinato$^*$ and M. G. Marafioti$^*$ and F. Pagliari$^*$
                      and J. Jansen$^*$ and I. Aversa$^*$ and R. Hanley$^*$ and C.
                      Nisticò$^*$ and D. Garcia-Calderón$^*$ and G. Genard$^*$
                      and J. F. Guerreiro and F. S. Costanzo and J. Seco$^*$},
      title        = {{L}ipid droplets and ferritin heavy chain: a devilish
                      liaison in human cancer cell radioresistance.},
      journal      = {eLife},
      volume       = {10},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DKFZ-2021-02007},
      pages        = {e72943},
      year         = {2021},
      note         = {#EA:E041#LA:E041#},
      abstract     = {Although much progress has been made in cancer treatment,
                      the molecular mechanisms underlying cancer radioresistance
                      (RR) as well as the biological signatures of radioresistant
                      cancer cells still need to be clarified. In this regard, we
                      discovered that breast, bladder, lung, neuroglioma and
                      prostate 6 Gy X-ray resistant cancer cells were
                      characterized by an increase of Lipid Droplet (LD) number
                      and that the cells containing highest LDs showed the highest
                      clonogenic potential after irradiation. Moreover, we
                      observed that LD content was tightly connected with the iron
                      metabolism and in particular with the presence of the
                      ferritin heavy chain (FTH1). In fact, breast and lung cancer
                      cells silenced for the FTH1 gene showed a reduction in the
                      LD numbers and, by consequence, became radiosensitive. FTH1
                      overexpression as well as iron-chelating treatment by
                      Deferoxamine were able to restore the LD amount and RR.
                      Overall, these results provide evidence of a novel mechanism
                      behind RR in which LDs and FTH1 are tightly connected to
                      each other, a synergistic effect which might be worth deeply
                      investigating in order to make cancer cells more
                      radiosensitive and improve the efficacy of radiation
                      treatments.},
      keywords     = {cancer biology (Other) / human (Other)},
      cin          = {E041},
      ddc          = {600},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34499029},
      doi          = {10.7554/eLife.72943},
      url          = {https://inrepo02.dkfz.de/record/170556},
}