TY  - JOUR
AU  - Jain, Deepali
AU  - Guleria, Prerna
AU  - Singh, Varsha
AU  - Parshad, Rajinder
AU  - Kumar, Sunil
AU  - Gaiser, Timo
AU  - Kurz, Katrin S
AU  - Ott, German
AU  - Porubsky, Stefan
AU  - Preissler, Gerhard
AU  - Sauer, Christian G
AU  - Schölch, Sebastian
AU  - Ströbel, Philipp
AU  - Hielscher, Thomas
AU  - Marx, Alexander
AU  - Popovic, Zoran V
TI  - GTF2I Mutation in Thymomas: Independence From Racial-Ethnic Backgrounds. An Indian/German Comparative Study.
JO  - Pathology & oncology research
VL  - 27
SN  - 1532-2807
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2021-02008
SP  - 1609858
PY  - 2021
AB  - Thymomas are the most frequent adult mediastinal cancers. Their etiology is unknown and their pathogenesis poorly understood. Racial, ethnic and environmental factors influence tumorigenesis in many cancers, but their role in thymomas remains unclear to date. In this study that included pretreatment thymoma cases from India and Germany (n = 37 and n = 77, respectively) we compared i) the prevalence of the thymoma-specific chromosome 7 c.74146970T > A mutation of the GTF2I gene in type A and AB thymomas; ii) epidemiological features; and iii) the frequency of myasthenia gravis (MG). Due to a known predominance of GTF2I mutation in A and AB histotypes, we included only a marginal number of type B thymomas as a control group in both cohorts. While the distribution of histological types between the cohorts was similar (p = 0.1622), Indian patients were strikingly younger (p < 0.0001; median age 50 vs. 65 years) and showed significantly lower tumour stage (Masaoka-Koga stage I) at primary diagnosis (p = 0.0005) than the German patients. In patients with known MG status (n = 17 in Indian and n = 25 in German cohort), a clear trend towards more frequent MG was observed in the Indian group (p = 0.0504; 48 vs. 82
KW  - GTF2I mutation (Other)
KW  - epidemiology (Other)
KW  - myasthenia gravis (Other)
KW  - racial-ethnic factors (Other)
KW  - thymoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34497477
C2  - pmc:PMC8419886
DO  - DOI:10.3389/pore.2021.1609858
UR  - https://inrepo02.dkfz.de/record/170557
ER  -