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@ARTICLE{Jain:170557,
      author       = {D. Jain and P. Guleria and V. Singh and R. Parshad and S.
                      Kumar and T. Gaiser and K. S. Kurz and G. Ott and S.
                      Porubsky and G. Preissler and C. G. Sauer and S.
                      Schölch$^*$ and P. Ströbel and T. Hielscher$^*$ and A.
                      Marx and Z. V. Popovic},
      title        = {{GTF}2{I} {M}utation in {T}hymomas: {I}ndependence {F}rom
                      {R}acial-{E}thnic {B}ackgrounds. {A}n {I}ndian/{G}erman
                      {C}omparative {S}tudy.},
      journal      = {Pathology $\&$ oncology research},
      volume       = {27},
      issn         = {1532-2807},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-02008},
      pages        = {1609858},
      year         = {2021},
      abstract     = {Thymomas are the most frequent adult mediastinal cancers.
                      Their etiology is unknown and their pathogenesis poorly
                      understood. Racial, ethnic and environmental factors
                      influence tumorigenesis in many cancers, but their role in
                      thymomas remains unclear to date. In this study that
                      included pretreatment thymoma cases from India and Germany
                      (n = 37 and n = 77, respectively) we compared i) the
                      prevalence of the thymoma-specific chromosome 7 c.74146970T
                      > A mutation of the GTF2I gene in type A and AB thymomas;
                      ii) epidemiological features; and iii) the frequency of
                      myasthenia gravis (MG). Due to a known predominance of GTF2I
                      mutation in A and AB histotypes, we included only a marginal
                      number of type B thymomas as a control group in both
                      cohorts. While the distribution of histological types
                      between the cohorts was similar (p = 0.1622), Indian
                      patients were strikingly younger (p < 0.0001; median age 50
                      vs. 65 years) and showed significantly lower tumour stage
                      (Masaoka-Koga stage I) at primary diagnosis (p = 0.0005)
                      than the German patients. In patients with known MG status
                      (n = 17 in Indian and n = 25 in German cohort), a clear
                      trend towards more frequent MG was observed in the Indian
                      group (p = 0.0504; 48 vs. $82\%).$ The prevalence of the
                      GTF2I mutation (analysed in n = 34 Indian and n = 77 German
                      patients) was identical in the two cohorts. We conclude that
                      racial-ethnic and environmental factors do not significantly
                      influence the most common molecular feature of thymomas but
                      may have an impact on the timing of clinical presentation.},
      keywords     = {GTF2I mutation (Other) / epidemiology (Other) / myasthenia
                      gravis (Other) / racial-ethnic factors (Other) / thymoma
                      (Other)},
      cin          = {A430 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)A430-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34497477},
      pmc          = {pmc:PMC8419886},
      doi          = {10.3389/pore.2021.1609858},
      url          = {https://inrepo02.dkfz.de/record/170557},
}