TY  - JOUR
AU  - Heisser, Thomas
AU  - Cardoso, Rafael
AU  - Guo, Feng
AU  - Moellers, Tobias
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Strongly Divergent Impact of Adherence Patterns on Efficacy of Colorectal Cancer Screening: The Need to Refine Adherence Statistics.
JO  - Clinical and translational gastroenterology
VL  - 12
IS  - 9
SN  - 2155-384X
CY  - London
PB  - Nature Publ. Group
M1  - DKFZ-2021-02019
SP  - e00399
PY  - 2021
N1  - #EA:C070#LA:C070#
AB  - The performance of colorectal cancer (CRC) screening programs depends on the adherence to screening offers. However, identical adherence levels may result from varying patterns of the population's screening behavior. We quantified the effects of different adherence patterns on the long-term performance of CRC screening for annual fecal immunochemical testing and screening colonoscopy at 10-year intervals.Using a multistate Markov model, we simulated scenarios where, while at the same overall adherence level, a certain proportion of the population adheres to all screening offers (selective adherence) or the entire population uses the screening offers at some point(s) of time, albeit not in the recommended frequency (sporadic adherence). Key outcomes for comparison were the numbers of prevented CRC cases and prevented CRC deaths after 50 simulated years.For screening with annual fecal immunochemical testing at adherence levels of 10
LB  - PUB:(DE-HGF)16
C6  - pmid:34506306
DO  - DOI:10.14309/ctg.0000000000000399
UR  - https://inrepo02.dkfz.de/record/170568
ER  -