TY  - JOUR
AU  - Hemminki, Kari
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Försti, Asta
AU  - Hemminki, Akseli
AU  - Li, Xinjun
TI  - Familial Risks and Proportions Describing Population Landscape of Familial Cancer.
JO  - Cancers
VL  - 13
IS  - 17
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-02022
SP  - 4385
PY  - 2021
AB  - Familial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family database in the world with complete family structures and medically confirmed cancers.We employed standardized incidence ratios (SIRs) to estimate familial risks for concordant cancer among first-degree relatives using the Swedish Cancer Registry from years 1958 through 2016.Cancer risks in a 20-84 year old population conferred by affected parents or siblings were about two-fold compared to the risk for individuals with unaffected relatives. For small intestinal, testicular, thyroid and bone cancers and Hodgkin disease, risks were higher, five-to-eight-fold. Novel familial associations included adult bone, lip, pharyngeal, and connective tissue cancers. Familial cancers were found in 13.2
KW  - familial proportion (Other)
KW  - familial risk (Other)
KW  - family-cancer database (Other)
KW  - high-risk families (Other)
KW  - nationwide study (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34503195
DO  - DOI:10.3390/cancers13174385
UR  - https://inrepo02.dkfz.de/record/170571
ER  -