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@ARTICLE{Hemminki:170571,
      author       = {K. Hemminki and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and A. Hemminki and X. Li},
      title        = {{F}amilial {R}isks and {P}roportions {D}escribing
                      {P}opulation {L}andscape of {F}amilial {C}ancer.},
      journal      = {Cancers},
      volume       = {13},
      number       = {17},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-02022},
      pages        = {4385},
      year         = {2021},
      abstract     = {Familial cancer can be defined through the occurrence of
                      the same cancer in two or more family members. We describe a
                      nationwide landscape of familial cancer, including its
                      frequency and the risk that it conveys, by using the largest
                      family database in the world with complete family structures
                      and medically confirmed cancers.We employed standardized
                      incidence ratios (SIRs) to estimate familial risks for
                      concordant cancer among first-degree relatives using the
                      Swedish Cancer Registry from years 1958 through 2016.Cancer
                      risks in a 20-84 year old population conferred by affected
                      parents or siblings were about two-fold compared to the risk
                      for individuals with unaffected relatives. For small
                      intestinal, testicular, thyroid and bone cancers and Hodgkin
                      disease, risks were higher, five-to-eight-fold. Novel
                      familial associations included adult bone, lip, pharyngeal,
                      and connective tissue cancers. Familial cancers were found
                      in $13.2\%$ of families with cancer; for prostate cancer,
                      the proportion was $26.4\%.$ High-risk families accounted
                      for $6.6\%$ of all cancer families.High-risk family history
                      should be exceedingly considered for management, including
                      targeted genetic testing. For the major proportion of
                      familial clustering, where genetic testing may not be
                      feasible, medical and behavioral intervention should be
                      indicated for the patient and their family members,
                      including screening recommendations and avoidance of
                      carcinogenic exposure.},
      keywords     = {familial proportion (Other) / familial risk (Other) /
                      family-cancer database (Other) / high-risk families (Other)
                      / nationwide study (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34503195},
      doi          = {10.3390/cancers13174385},
      url          = {https://inrepo02.dkfz.de/record/170571},
}