%0 Journal Article
%A Tian, Yu
%A Kharazmi, Elhamalsadat
%A Brenner, Hermann
%A Xu, Xing
%A Sundquist, Kristina
%A Sundquist, Jan
%A Fallah, Mahdi
%T Importance of Family History of Colorectal Cancer In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study.
%J Journal of the National Comprehensive Cancer Network
%V 19
%N 11
%@ 1540-1405
%C Cold Spring Harbor, NY
%I Harborside Press
%M DKFZ-2021-02038
%P 1252-1257
%D 2021
%Z #EA:C120#LA:C120# / Volume 19: Issue 11 1252-1257
%X The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature.We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period from 1958 to 2015. Of 12,829,251 individuals with available genealogical data, 173,796 were diagnosed with CRC and 40,558 with CCIS.The lifetime (0-79 years) cumulative risk of CRC in first-degree relatives of patients with CCIS was 6.5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34517339
%R 10.6004/jnccn.2021.7004
%U https://inrepo02.dkfz.de/record/170589