000170589 001__ 170589
000170589 005__ 20240229133718.0
000170589 0247_ $$2pmid$$apmid:34517339
000170589 0247_ $$2ISSN$$a1540-1405
000170589 0247_ $$2ISSN$$a1540-1413
000170589 0247_ $$2doi$$a DOI: 10.6004/jnccn.2021.7004 
000170589 0247_ $$2doi$$aDOI: 10.6004/jnccn.2021.7004
000170589 0247_ $$2altmetric$$aaltmetric:113412859
000170589 037__ $$aDKFZ-2021-02038
000170589 041__ $$aEnglish
000170589 082__ $$a610
000170589 1001_ $$0P:(DE-He78)834e8bc4d74592e3b999100c157215f5$$aTian, Yu$$b0$$eFirst author
000170589 245__ $$aImportance of Family History of Colorectal Cancer In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study.
000170589 260__ $$aCold Spring Harbor, NY$$bHarborside Press$$c2021
000170589 3367_ $$2DRIVER$$aarticle
000170589 3367_ $$2DataCite$$aOutput Types/Journal article
000170589 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1642679828_13781
000170589 3367_ $$2BibTeX$$aARTICLE
000170589 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000170589 3367_ $$00$$2EndNote$$aJournal Article
000170589 500__ $$a#EA:C120#LA:C120# / Volume 19: Issue 11 1252-1257
000170589 520__ $$aThe aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature.We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period from 1958 to 2015. Of 12,829,251 individuals with available genealogical data, 173,796 were diagnosed with CRC and 40,558 with CCIS.The lifetime (0-79 years) cumulative risk of CRC in first-degree relatives of patients with CCIS was 6.5%, which represents a 1.6-fold (95% CI, 1.5-1.7; n=752) increased risk. A similarly increased lifetime cumulative risk (6.7%) was found among first-degree relatives of patients with CRC (SIR, 1.6; 95% CI, 1.6-1.7; n=6,965). An increased risk of CRC was also found in half-siblings of patients with CCIS (SIR, 1.9; 95% CI, 1.1-3.0; n=18) and also in half-siblings of patients with CRC (SIR, 1.7; 95% CI, 1.3-2.1; n=78). Moreover, the increased risk of CRC was higher for younger age at diagnosis of CCIS in the affected first-degree relative and for younger age at diagnosis of CRC in the index person.Results of this study show that first-degree relatives and half-siblings of patients with CCIS have an increased risk of CRC, which is comparable in magnitude to the risk of those with a family history of invasive CRC. These findings extend available evidence on familial risk of CRC and may help to refine guidelines and recommendations for CRC screening.
000170589 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000170589 588__ $$aDataset connected to DataCite, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000170589 7001_ $$0P:(DE-He78)e56510c7dedbff7a279ad76dad80eeda$$aKharazmi, Elhamalsadat$$b1$$eFirst author
000170589 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b2
000170589 7001_ $$0P:(DE-He78)62b0f1b5eccef2b5f2e55b7f13ccde6d$$aXu, Xing$$b3
000170589 7001_ $$aSundquist, Kristina$$b4
000170589 7001_ $$aSundquist, Jan$$b5
000170589 7001_ $$0P:(DE-He78)b510b884502b619724039bf33fdae68a$$aFallah, Mahdi$$b6$$eLast author
000170589 773__ $$0PERI:(DE-600)2134524-7$$a10.6004/jnccn.2021.7004$$n11$$p1252-1257$$tJournal of the National Comprehensive Cancer Network$$v19$$x1540-1405$$y2021
000170589 909CO $$ooai:inrepo02.dkfz.de:170589$$pVDB
000170589 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)834e8bc4d74592e3b999100c157215f5$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000170589 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e56510c7dedbff7a279ad76dad80eeda$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000170589 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000170589 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)62b0f1b5eccef2b5f2e55b7f13ccde6d$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000170589 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b510b884502b619724039bf33fdae68a$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000170589 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000170589 9141_ $$y2021
000170589 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NATL COMPR CANC NE : 2019$$d2021-02-02
000170589 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ NATL COMPR CANC NE : 2019$$d2021-02-02
000170589 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x0
000170589 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x1
000170589 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000170589 980__ $$ajournal
000170589 980__ $$aVDB
000170589 980__ $$aI:(DE-He78)C120-20160331
000170589 980__ $$aI:(DE-He78)C070-20160331
000170589 980__ $$aI:(DE-He78)HD01-20160331
000170589 980__ $$aUNRESTRICTED