TY  - JOUR
AU  - Tian, Yu
AU  - Kharazmi, Elhamalsadat
AU  - Brenner, Hermann
AU  - Xu, Xing
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Fallah, Mahdi
TI  - Importance of Family History of Colorectal Cancer In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study.
JO  - Journal of the National Comprehensive Cancer Network
VL  - 19
IS  - 11
SN  - 1540-1405
CY  - Cold Spring Harbor, NY
PB  - Harborside Press
M1  - DKFZ-2021-02038
SP  - 1252-1257
PY  - 2021
N1  - #EA:C120#LA:C120# / Volume 19: Issue 11 1252-1257
AB  - The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature.We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period from 1958 to 2015. Of 12,829,251 individuals with available genealogical data, 173,796 were diagnosed with CRC and 40,558 with CCIS.The lifetime (0-79 years) cumulative risk of CRC in first-degree relatives of patients with CCIS was 6.5
LB  - PUB:(DE-HGF)16
C6  - pmid:34517339
DO  - DOI:10.6004/jnccn.2021.7004
UR  - https://inrepo02.dkfz.de/record/170589
ER  -