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@ARTICLE{Tian:170589,
      author       = {Y. Tian$^*$ and E. Kharazmi$^*$ and H. Brenner$^*$ and X.
                      Xu$^*$ and K. Sundquist and J. Sundquist and M. Fallah$^*$},
      title        = {{I}mportance of {F}amily {H}istory of {C}olorectal {C}ancer
                      {I}n {S}itu {V}ersus {I}nvasive {C}olorectal {C}ancer: {A}
                      {N}ationwide {C}ohort {S}tudy.},
      journal      = {Journal of the National Comprehensive Cancer Network},
      volume       = {19},
      number       = {11},
      issn         = {1540-1405},
      address      = {Cold Spring Harbor, NY},
      publisher    = {Harborside Press},
      reportid     = {DKFZ-2021-02038},
      pages        = {1252-1257},
      year         = {2021},
      note         = {#EA:C120#LA:C120# / Volume 19: Issue 11 1252-1257},
      abstract     = {The aim of this study was to explore the risk of invasive
                      colorectal cancer (CRC) in relatives of patients with
                      colorectal carcinoma in situ (CCIS), which is lacking in the
                      literature.We collected data from Swedish family-cancer
                      datasets and calculated standardized incidence ratio (SIR)
                      and cumulative risk of CRC in family histories of CCIS in
                      first- and second-degree relatives. Family history was
                      defined as a dynamic (time-dependent) variable allowing for
                      changes during the follow-up period from 1958 to 2015. Of
                      12,829,251 individuals with available genealogical data,
                      173,796 were diagnosed with CRC and 40,558 with CCIS.The
                      lifetime (0-79 years) cumulative risk of CRC in first-degree
                      relatives of patients with CCIS was $6.5\%,$ which
                      represents a 1.6-fold $(95\%$ CI, 1.5-1.7; n=752) increased
                      risk. A similarly increased lifetime cumulative risk
                      $(6.7\%)$ was found among first-degree relatives of patients
                      with CRC (SIR, 1.6; $95\%$ CI, 1.6-1.7; n=6,965). An
                      increased risk of CRC was also found in half-siblings of
                      patients with CCIS (SIR, 1.9; $95\%$ CI, 1.1-3.0; n=18) and
                      also in half-siblings of patients with CRC (SIR, 1.7; $95\%$
                      CI, 1.3-2.1; n=78). Moreover, the increased risk of CRC was
                      higher for younger age at diagnosis of CCIS in the affected
                      first-degree relative and for younger age at diagnosis of
                      CRC in the index person.Results of this study show that
                      first-degree relatives and half-siblings of patients with
                      CCIS have an increased risk of CRC, which is comparable in
                      magnitude to the risk of those with a family history of
                      invasive CRC. These findings extend available evidence on
                      familial risk of CRC and may help to refine guidelines and
                      recommendations for CRC screening.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34517339},
      doi          = {10.6004/jnccn.2021.7004},
      url          = {https://inrepo02.dkfz.de/record/170589},
}