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@ARTICLE{Aglago:172519,
      author       = {E. K. Aglago and A.-L. Mayén and V. Knaze and H. Freisling
                      and V. Fedirko and D. J. Hughes and L. Jiao and A. K.
                      Eriksen and A. Tjønneland and M.-C. Boutron-Ruault and J.
                      A. Rothwell and G. Severi and R. Kaaks$^*$ and V. Katzke$^*$
                      and M. B. Schulze and A. Birukov and D. Palli and S. Sieri
                      and M. Santucci de Magistris and R. Tumino and F. Ricceri
                      and B. Bueno-de-Mesquita and J. W. G. Derksen and G. Skeie
                      and I. T. Gram and T. Sandanger and J. R. Quirós and L.
                      Luján-Barroso and M.-J. Sánchez and P. Amiano and M.-D.
                      Chirlaque and A. B. Gurrea and I. Johansson and J. Manjer
                      and A. Perez-Cornago and E. Weiderpass and M. J. Gunter and
                      A. K. Heath and C. G. Schalkwijk and M. Jenab},
      title        = {{D}ietary {A}dvanced {G}lycation {E}nd-{P}roducts and
                      {C}olorectal {C}ancer {R}isk in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition ({EPIC})
                      {S}tudy.},
      journal      = {Nutrients},
      volume       = {13},
      number       = {9},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-02067},
      pages        = {3132},
      year         = {2021},
      abstract     = {Dietary advanced glycation end-products (dAGEs) have been
                      hypothesized to be associated with a higher risk of
                      colorectal cancer (CRC) by promoting inflammation, metabolic
                      dysfunction, and oxidative stress in the colonic epithelium.
                      However, evidence from prospective cohort studies is scarce
                      and inconclusive. We evaluated CRC risk associated with the
                      intake of dAGEs in the European Prospective Investigation
                      into Cancer and Nutrition (EPIC) study. Dietary intakes of
                      three major dAGEs: Nε-carboxy-methyllysine (CML),
                      Nε-carboxyethyllysine (CEL), and
                      Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1)
                      were estimated in 450,111 participants (median follow-up =
                      13 years, with 6162 CRC cases) by matching to a detailed
                      published European food composition database. Hazard ratios
                      (HRs) and $95\%$ confidence intervals (CIs) for the
                      associations of dAGEs with CRC were computed using
                      multivariable-adjusted Cox regression models. Inverse CRC
                      risk associations were observed for CML (HR comparing
                      extreme quintiles: HRQ5vs.Q1 = 0.92, $95\%$ CI = 0.85-1.00)
                      and MG-H1 (HRQ5vs.Q1 = 0.92, $95\%$ CI = 0.85-1.00), but not
                      for CEL (HRQ5vs.Q1 = 0.97, $95\%$ CI = 0.89-1.05). The
                      associations did not differ by sex or anatomical location of
                      the tumor. Contrary to the initial hypothesis, our findings
                      suggest an inverse association between dAGEs and CRC risk.
                      More research is required to verify these findings and
                      better differentiate the role of dAGEs from that of
                      endogenously produced AGEs and their precursor compounds in
                      CRC development.},
      keywords     = {advanced glycation end-products (Other) / colorectal cancer
                      (Other) / dietary exposure (Other) / dietary glycation
                      compounds (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34579010},
      pmc          = {pmc:PMC8470201},
      doi          = {10.3390/nu13093132},
      url          = {https://inrepo02.dkfz.de/record/172519},
}