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@ARTICLE{Hirsch:172546,
      author       = {S. Hirsch and N. Dikow and S. M. Pfister$^*$ and K.
                      Pajtler$^*$},
      title        = {{C}ancer predisposition in pediatric
                      neuro-oncology-practical approaches and ethical
                      considerations.},
      journal      = {Neuro-oncology practice},
      volume       = {8},
      number       = {5},
      issn         = {2054-2585},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2021-02094},
      pages        = {526 - 538},
      year         = {2021},
      note         = {#LA:B062#},
      abstract     = {A genetic predisposition to tumor development can be
                      identified in up to $10\%$ of pediatric patients with
                      central nervous system (CNS) tumors. For some entities, the
                      rate of an underlying predisposition is even considerably
                      higher. In recent years, population-based approaches have
                      helped to further delineate the role of cancer
                      predisposition in pediatric oncology. Investigations for
                      cancer predisposition syndrome (CPS) can be guided by
                      clinical signs and family history leading to directed
                      testing of specific genes. The increasingly adopted
                      molecular analysis of tumor and often parallel blood samples
                      with multi-gene panel, whole-exome, or whole-genome
                      sequencing identifies additional patients with or without
                      clinical signs. Diagnosis of a genetic predisposition may
                      put an additional burden on affected families. However,
                      information on a given cancer predisposition may be critical
                      for the patient as potentially influences treatment
                      decisions and may offer the patient and healthy carriers the
                      chance to take part in intensified surveillance programs
                      aiming at early tumor detection. In this review, we discuss
                      some of the practical and ethical challenges resulting from
                      the widespread use of new diagnostic techniques and the most
                      important CPS that may manifest with brain tumors in
                      childhood.},
      subtyp        = {Review Article},
      keywords     = {cancer (Other) / genetics (Other) / pediatrics (Other) /
                      predisposition (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34594567},
      pmc          = {pmc:PMC8475219},
      doi          = {10.1093/nop/npab031},
      url          = {https://inrepo02.dkfz.de/record/172546},
}