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000176891 1001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b0$$eFirst author$$udkfz
000176891 245__ $$aAre circulating immune cells a determinant of pancreatic cancer risk? A prospective study using epigenetic cell count measures.
000176891 260__ $$aPhiladelphia, Pa.$$bAACR$$c2021
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000176891 500__ $$a#EA:C020#LA:C020# / 2021 Dec;30(12):2179-2187
000176891 520__ $$aEvidence is accumulating that immune cells play a prominent role in pancreatic cancer aetiology but prospective investigations are missing.We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sub-lineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells (Tregs) relative to nucleated cells, (white blood cells) were measured by qRT-PCR. Odds ratios with 95% Confidence Intervals were estimated using logistic regressions, modelling relative counts of immune cells on a continuous scale.Neither relative counts of immune cell types taken individually, nor mutually adjusted for each other were associated with pancreatic cancer risks. However, in sub-group analyses by strata of lag-time, higher relative counts of Tregs and lower relative counts of CD8+ were significantly associated with an increased pancreatic cancer risks in participants diagnosed within the first 5 years of follow-up.These results might reflect reverse causation, due to higher relative counts of Tregs and lower counts of CD8+ cells among individuals with more advanced stages of latent pancreatic cancer, who are closer to the point of developing clinical manifest disease.We have shown, for the first time, that increased relative counts of regulatory T-cells and lower relative counts of CD8+, cytotoxic T cells may be associated with pancreatic cancer risk or relatively late-stage tumor development.
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000176891 7001_ $$0P:(DE-He78)2d4cac0f4bf270325b98fe07036dc6c6$$aLe Cornet, Charlotte$$b1$$udkfz
000176891 7001_ $$aMahfouz, Rayaan$$b2
000176891 7001_ $$aBrauer, Bianca$$b3
000176891 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron Scot$$b4$$udkfz
000176891 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b5$$udkfz
000176891 7001_ $$aRebours, Vinciane$$b6
000176891 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b7
000176891 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b8
000176891 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b9
000176891 7001_ $$aOlsen, Anja$$b10
000176891 7001_ $$aTjoenneland, Anne$$b11
000176891 7001_ $$aOvervad, Kim$$b12
000176891 7001_ $$aCrous-Bou, Marta$$b13
000176891 7001_ $$aMolina-Montes, Esther$$b14
000176891 7001_ $$aAmiano, Pilar$$b15
000176891 7001_ $$00000-0002-9637-3869$$aHuerta, José María$$b16
000176891 7001_ $$00000-0001-8434-2013$$aArdanaz, Eva$$b17
000176891 7001_ $$00000-0002-5652-356X$$aPerez-Cornago, Aurora$$b18
000176891 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b19
000176891 7001_ $$00000-0001-5438-970X$$aPala, Valeria$$b20
000176891 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b21
000176891 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b22
000176891 7001_ $$aPanico, Salvatore$$b23
000176891 7001_ $$aBueno-de-Mesquita, Bas$$b24
000176891 7001_ $$00000-0003-4082-8163$$aVermeulen, Roel$$b25
000176891 7001_ $$00000-0002-7516-9543$$aSund, Malin$$b26
000176891 7001_ $$00000-0002-3777-6887$$aFranklin, Oskar$$b27
000176891 7001_ $$aChristakoudi, Sofia$$b28
000176891 7001_ $$00000-0003-2716-5748$$aDossus, Laure$$b29
000176891 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b30
000176891 7001_ $$aOlek, Sven$$b31
000176891 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b32$$eLast author$$udkfz
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