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@ARTICLE{Katzke:176891,
      author       = {V. Katzke$^*$ and C. Le Cornet$^*$ and R. Mahfouz and B.
                      Brauer and T. S. Johnson$^*$ and F. Canzian$^*$ and V.
                      Rebours and M.-C. Boutron-Ruault and G. Severi and M. B.
                      Schulze and A. Olsen and A. Tjoenneland and K. Overvad and
                      M. Crous-Bou and E. Molina-Montes and P. Amiano and J. M.
                      Huerta and E. Ardanaz and A. Perez-Cornago and G. Masala and
                      V. Pala and R. Tumino and C. Sacerdote and S. Panico and B.
                      Bueno-de-Mesquita and R. Vermeulen and M. Sund and O.
                      Franklin and S. Christakoudi and L. Dossus and E. Weiderpass
                      and S. Olek and R. Kaaks$^*$},
      title        = {{A}re circulating immune cells a determinant of pancreatic
                      cancer risk? {A} prospective study using epigenetic cell
                      count measures.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {30},
      number       = {12},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-02133},
      pages        = {2179-2187},
      year         = {2021},
      note         = {#EA:C020#LA:C020# / 2021 Dec;30(12):2179-2187},
      abstract     = {Evidence is accumulating that immune cells play a prominent
                      role in pancreatic cancer aetiology but prospective
                      investigations are missing.We conducted a nested
                      case-control study within the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study with
                      502 pairs of incident pancreatic cancer cases and matched
                      controls. Relative counts of circulating immune cells
                      (neutrophils and lymphocyte sub-lineages: total CD3+, CD8+,
                      CD4+, and FOXP3+ regulatory T cells (Tregs) relative to
                      nucleated cells, (white blood cells) were measured by
                      qRT-PCR. Odds ratios with $95\%$ Confidence Intervals were
                      estimated using logistic regressions, modelling relative
                      counts of immune cells on a continuous scale.Neither
                      relative counts of immune cell types taken individually, nor
                      mutually adjusted for each other were associated with
                      pancreatic cancer risks. However, in sub-group analyses by
                      strata of lag-time, higher relative counts of Tregs and
                      lower relative counts of CD8+ were significantly associated
                      with an increased pancreatic cancer risks in participants
                      diagnosed within the first 5 years of follow-up.These
                      results might reflect reverse causation, due to higher
                      relative counts of Tregs and lower counts of CD8+ cells
                      among individuals with more advanced stages of latent
                      pancreatic cancer, who are closer to the point of developing
                      clinical manifest disease.We have shown, for the first time,
                      that increased relative counts of regulatory T-cells and
                      lower relative counts of CD8+, cytotoxic T cells may be
                      associated with pancreatic cancer risk or relatively
                      late-stage tumor development.},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34548327},
      doi          = {10.1158/1055-9965.EPI-21-0169},
      url          = {https://inrepo02.dkfz.de/record/176891},
}