000176923 001__ 176923 000176923 005__ 20240229133724.0 000176923 0247_ $$2doi$$a10.1002/pon.5830 000176923 0247_ $$2pmid$$apmid:34591369 000176923 0247_ $$2ISSN$$a1057-9249 000176923 0247_ $$2ISSN$$a1099-1611 000176923 0247_ $$2altmetric$$aaltmetric:114461591 000176923 037__ $$aDKFZ-2021-02163 000176923 041__ $$aEnglish 000176923 082__ $$a610 000176923 1001_ $$00000-0001-8898-8292$$aPatterson, Joanne M$$b0 000176923 245__ $$aAssociations between markers of social functioning and depression and quality of life in survivors of head and neck cancer: Findings from the Head and Neck Cancer 5000 study. 000176923 260__ $$aNew York, NY [u.a.]$$bWiley$$c2022 000176923 3367_ $$2DRIVER$$aarticle 000176923 3367_ $$2DataCite$$aOutput Types/Journal article 000176923 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1647591747_22711 000176923 3367_ $$2BibTeX$$aARTICLE 000176923 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000176923 3367_ $$00$$2EndNote$$aJournal Article 000176923 500__ $$aVolume31, Issue3, March 2022, Pages 478-485 000176923 520__ $$aTo investigate associations between markers of social functioning (trouble with social eating and social contact), depression and health-related quality of life (QOL) among head and neck cancer survivors.This cross-sectional analysis included individuals with oral cavity, oropharynx, larynx, salivary gland and thyroid cancers from Head and Neck 5000 alive at 12 months. Trouble with social eating and social contact were measured using items from EORTC QLQ-H&N35 and QOL using EORTC QLQ-C30; responses were converted into a score of 0-100, with a higher score equalling more trouble or better QOL. A HADS subscale score of ≥8 was considered significant depression. Associations between tertiles of trouble with social eating and social contact and depression and QoL were assessed using multivariable logistic and linear regression (with robust errors), respectively.Of 2561 survivors, 23% reported significant depression. The median QOL score was 75.0 (interquartile range 58.3-83.3). For trouble with social eating, after confounder adjustment, those in the intermediate and highest tertiles had higher odds of depression (intermediate: OR = 4.5, 95% CI 3.19-6.45; high: OR = 21.8, 15.17-31.18) and lower QOL (intermediate:β = -8.7, 95% CI -10.35 to -7.14; high: β = -24.8, -26.91 to -22.77). Results were similar for trouble with social contact.We found strong clinically important associations between markers of social functioning and depression and QOL. More effective interventions addressing social eating and contact are required. These may help survivors regain their independence, reduce levels of isolation and loneliness, and depression, and improve QOL outcomes generally. 000176923 536__ $$0G:(DE-HGF)POF4-316$$a316 - Infektionen, Entzündung und Krebs (POF4-316)$$cPOF4-316$$fPOF IV$$x0 000176923 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de 000176923 650_7 $$2Other$$aHN5000 000176923 650_7 $$2Other$$aHead and Neck Cancer 000176923 650_7 $$2Other$$adepression 000176923 650_7 $$2Other$$adysphagia 000176923 650_7 $$2Other$$aoncology 000176923 650_7 $$2Other$$apsycho-oncology 000176923 650_7 $$2Other$$aquality of life 000176923 650_7 $$2Other$$asocial contact 000176923 650_7 $$2Other$$asocial eating 000176923 650_7 $$2Other$$asocial functioning 000176923 7001_ $$aLu, Liya$$b1 000176923 7001_ $$aWatson, Laura-Jayne$$b2 000176923 7001_ $$aHarding, Sam$$b3 000176923 7001_ $$aNess, Andy R$$b4 000176923 7001_ $$aThomas, Steve$$b5 000176923 7001_ $$aWaylen, Andrea$$b6 000176923 7001_ $$aPring, Miranda$$b7 000176923 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, Tim$$b8$$udkfz 000176923 7001_ $$00000-0001-9515-1722$$aSharp, Linda$$b9 000176923 773__ $$0PERI:(DE-600)1495115-0$$a10.1002/pon.5830$$gp. pon.5830$$n3$$p478-485$$tPsycho-oncology$$v31$$x1099-1611$$y2022 000176923 909CO $$ooai:inrepo02.dkfz.de:176923$$pVDB 000176923 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ 000176923 9131_ $$0G:(DE-HGF)POF4-316$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vInfektionen, Entzündung und Krebs$$x0 000176923 9141_ $$y2021 000176923 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2021-01-28$$wger 000176923 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-28 000176923 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-28 000176923 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2022-11-15$$wger 000176923 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)1180$$2StatID$$aDBCoverage$$bCurrent Contents - Social and Behavioral Sciences$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0130$$2StatID$$aDBCoverage$$bSocial Sciences Citation Index$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPSYCHO-ONCOLOGY : 2021$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-15 000176923 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-15 000176923 9201_ $$0I:(DE-He78)F022-20160331$$kF022$$lInfektionen und Krebs-Epidemiologie$$x0 000176923 9201_ $$0I:(DE-He78)F020-20160331$$kF020$$lInfektionen und Krebs-Epidemiologie$$x1 000176923 980__ $$ajournal 000176923 980__ $$aVDB 000176923 980__ $$aI:(DE-He78)F022-20160331 000176923 980__ $$aI:(DE-He78)F020-20160331 000176923 980__ $$aUNRESTRICTED