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@ARTICLE{Patterson:176923,
      author       = {J. M. Patterson and L. Lu and L.-J. Watson and S. Harding
                      and A. R. Ness and S. Thomas and A. Waylen and M. Pring and
                      T. Waterboer$^*$ and L. Sharp},
      title        = {{A}ssociations between markers of social functioning and
                      depression and quality of life in survivors of head and neck
                      cancer: {F}indings from the {H}ead and {N}eck {C}ancer 5000
                      study.},
      journal      = {Psycho-oncology},
      volume       = {31},
      number       = {3},
      issn         = {1099-1611},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2021-02163},
      pages        = {478-485},
      year         = {2022},
      note         = {Volume31, Issue3, March 2022, Pages 478-485},
      abstract     = {To investigate associations between markers of social
                      functioning (trouble with social eating and social contact),
                      depression and health-related quality of life (QOL) among
                      head and neck cancer survivors.This cross-sectional analysis
                      included individuals with oral cavity, oropharynx, larynx,
                      salivary gland and thyroid cancers from Head and Neck 5000
                      alive at 12 months. Trouble with social eating and social
                      contact were measured using items from EORTC $QLQ-H\&N35$
                      and QOL using EORTC QLQ-C30; responses were converted into a
                      score of 0-100, with a higher score equalling more trouble
                      or better QOL. A HADS subscale score of ≥8 was considered
                      significant depression. Associations between tertiles of
                      trouble with social eating and social contact and depression
                      and QoL were assessed using multivariable logistic and
                      linear regression (with robust errors), respectively.Of 2561
                      survivors, $23\%$ reported significant depression. The
                      median QOL score was 75.0 (interquartile range 58.3-83.3).
                      For trouble with social eating, after confounder adjustment,
                      those in the intermediate and highest tertiles had higher
                      odds of depression (intermediate: OR = 4.5, $95\%$ CI
                      3.19-6.45; high: OR = 21.8, 15.17-31.18) and lower QOL
                      (intermediate:β = -8.7, $95\%$ CI -10.35 to -7.14; high:
                      β = -24.8, -26.91 to -22.77). Results were similar for
                      trouble with social contact.We found strong clinically
                      important associations between markers of social functioning
                      and depression and QOL. More effective interventions
                      addressing social eating and contact are required. These may
                      help survivors regain their independence, reduce levels of
                      isolation and loneliness, and depression, and improve QOL
                      outcomes generally.},
      keywords     = {HN5000 (Other) / Head and Neck Cancer (Other) / depression
                      (Other) / dysphagia (Other) / oncology (Other) /
                      psycho-oncology (Other) / quality of life (Other) / social
                      contact (Other) / social eating (Other) / social functioning
                      (Other)},
      cin          = {F022 / F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34591369},
      doi          = {10.1002/pon.5830},
      url          = {https://inrepo02.dkfz.de/record/176923},
}