%0 Journal Article
%A Lu, Ye
%A Corradi, Chiara
%A Gentiluomo, Manuel
%A López de Maturana, Evangelina
%A Theodoropoulos, George E
%A Roth, Susanne
%A Maiello, Evaristo
%A Morelli, Luca
%A Archibugi, Livia
%A Izbicki, Jakob R
%A Sarlós, Patricia
%A Kiudelis, Vytautas
%A Oliverius, Martin
%A Aoki, Mateus Nóbrega
%A Vashist, Yogesh
%A van Eijck, Casper H J
%A Gazouli, Maria
%A Talar-Wojnarowska, Renata
%A Mambrini, Andrea
%A Pezzilli, Raffaele
%A Bueno-de-Mesquita, Bas
%A Hegyi, Péter
%A Souček, Pavel
%A Neoptolemos, John P
%A Di Franco, Gregorio
%A Sperti, Cosimo
%A Kauffmann, Emanuele F
%A Hlaváč, Viktor
%A Uzunoğlu, Faik G
%A Ermini, Stefano
%A Małecka-Panas, Ewa
%A Lucchesi, Maurizio
%A Vanella, Giuseppe
%A Dijk, Frederike
%A Mohelníková-Duchoňová, Beatrice
%A Bambi, Franco
%A Petrone, Maria Chiara
%A Jamroziak, Krzysztof
%A Guo, Feng
%A Kolarova, Katerina
%A Capretti, Giovanni
%A Milanetto, Anna Caterina
%A Ginocchi, Laura
%A Loveček, Martin
%A Puzzono, Marta
%A van Laarhoven, Hanneke W M
%A Carrara, Silvia
%A Ivanauskas, Audrius
%A Papiris, Konstantinos
%A Basso, Daniela
%A Arcidiacono, Paolo G
%A Izbéki, Ferenc
%A Chammas, Roger
%A Vodicka, Pavel
%A Hackert, Thilo
%A Pasquali, Claudio
%A Piredda, Maria L
%A Costello-Goldring, Eithne
%A Cavestro, Giulia Martina
%A Szentesi, Andrea
%A Tavano, Francesca
%A Włodarczyk, Barbara
%A Brenner, Hermann
%A Kreivenaite, Edita
%A Gao, Xin
%A Bunduc, Stefania
%A Vermeulen, Roel C H
%A Schneider, Martin A
%A Latiano, Anna
%A Gioffreda, Domenica
%A Testoni, Sabrina G G
%A Kupcinskas, Juozas
%A Lawlor, Rita T
%A Capurso, Gabriele
%A Malats, Núria
%A Campa, Daniele
%A Canzian, Federico
%T Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.
%J Frontiers in genetics
%V 12
%@ 1664-8021
%C Lausanne
%I Frontiers Media
%M DKFZ-2021-02176
%P 693933
%D 2021
%Z #EA:C055#LA:C055#
%X Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case-Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95
%K genetic polymorphisms (Other)
%K miRNA (Other)
%K pancreatic cancer (Other)
%K pancreatic ductal adenocarcinoma (Other)
%K susceptibility (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34527018
%2 pmc:PMC8435735
%R 10.3389/fgene.2021.693933
%U https://inrepo02.dkfz.de/record/176936