000176936 001__ 176936
000176936 005__ 20240229133725.0
000176936 0247_ $$2doi$$a10.3389/fgene.2021.693933
000176936 0247_ $$2pmid$$apmid:34527018
000176936 0247_ $$2pmc$$apmc:PMC8435735
000176936 0247_ $$2altmetric$$aaltmetric:112579256
000176936 037__ $$aDKFZ-2021-02176
000176936 041__ $$aEnglish
000176936 082__ $$a570
000176936 1001_ $$0P:(DE-He78)ebb819874e9553d89bd480e6811dc0f3$$aLu, Ye$$b0$$eFirst author$$udkfz
000176936 245__ $$aAssociation of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.
000176936 260__ $$aLausanne$$bFrontiers Media$$c2021
000176936 3367_ $$2DRIVER$$aarticle
000176936 3367_ $$2DataCite$$aOutput Types/Journal article
000176936 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634036444_10607
000176936 3367_ $$2BibTeX$$aARTICLE
000176936 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000176936 3367_ $$00$$2EndNote$$aJournal Article
000176936 500__ $$a#EA:C055#LA:C055#
000176936 520__ $$aGenetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case-Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95% CI 1.07-1.17, p = 3.03 × 10-6 in the meta-analysis). This SNP is in linkage disequilibrium (LD) with rs2274048, which modulates binding of various miRNAs to the 3'UTR of UCHL3, a gene involved in PC progression. In conclusion, our results expand the knowledge of the genetic PC risk through miRNA-related SNPs and show the usefulness of functional prioritization to identify genetic polymorphisms associated with PC risk.
000176936 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000176936 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000176936 650_7 $$2Other$$agenetic polymorphisms
000176936 650_7 $$2Other$$amiRNA
000176936 650_7 $$2Other$$apancreatic cancer
000176936 650_7 $$2Other$$apancreatic ductal adenocarcinoma
000176936 650_7 $$2Other$$asusceptibility
000176936 7001_ $$aCorradi, Chiara$$b1
000176936 7001_ $$aGentiluomo, Manuel$$b2
000176936 7001_ $$aLópez de Maturana, Evangelina$$b3
000176936 7001_ $$aTheodoropoulos, George E$$b4
000176936 7001_ $$aRoth, Susanne$$b5
000176936 7001_ $$aMaiello, Evaristo$$b6
000176936 7001_ $$aMorelli, Luca$$b7
000176936 7001_ $$aArchibugi, Livia$$b8
000176936 7001_ $$aIzbicki, Jakob R$$b9
000176936 7001_ $$aSarlós, Patricia$$b10
000176936 7001_ $$aKiudelis, Vytautas$$b11
000176936 7001_ $$aOliverius, Martin$$b12
000176936 7001_ $$aAoki, Mateus Nóbrega$$b13
000176936 7001_ $$aVashist, Yogesh$$b14
000176936 7001_ $$avan Eijck, Casper H J$$b15
000176936 7001_ $$aGazouli, Maria$$b16
000176936 7001_ $$aTalar-Wojnarowska, Renata$$b17
000176936 7001_ $$aMambrini, Andrea$$b18
000176936 7001_ $$aPezzilli, Raffaele$$b19
000176936 7001_ $$aBueno-de-Mesquita, Bas$$b20
000176936 7001_ $$aHegyi, Péter$$b21
000176936 7001_ $$aSouček, Pavel$$b22
000176936 7001_ $$aNeoptolemos, John P$$b23
000176936 7001_ $$aDi Franco, Gregorio$$b24
000176936 7001_ $$aSperti, Cosimo$$b25
000176936 7001_ $$aKauffmann, Emanuele F$$b26
000176936 7001_ $$aHlaváč, Viktor$$b27
000176936 7001_ $$aUzunoğlu, Faik G$$b28
000176936 7001_ $$aErmini, Stefano$$b29
000176936 7001_ $$aMałecka-Panas, Ewa$$b30
000176936 7001_ $$aLucchesi, Maurizio$$b31
000176936 7001_ $$aVanella, Giuseppe$$b32
000176936 7001_ $$aDijk, Frederike$$b33
000176936 7001_ $$aMohelníková-Duchoňová, Beatrice$$b34
000176936 7001_ $$aBambi, Franco$$b35
000176936 7001_ $$aPetrone, Maria Chiara$$b36
000176936 7001_ $$aJamroziak, Krzysztof$$b37
000176936 7001_ $$0P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aGuo, Feng$$b38$$udkfz
000176936 7001_ $$aKolarova, Katerina$$b39
000176936 7001_ $$aCapretti, Giovanni$$b40
000176936 7001_ $$aMilanetto, Anna Caterina$$b41
000176936 7001_ $$aGinocchi, Laura$$b42
000176936 7001_ $$aLoveček, Martin$$b43
000176936 7001_ $$aPuzzono, Marta$$b44
000176936 7001_ $$avan Laarhoven, Hanneke W M$$b45
000176936 7001_ $$aCarrara, Silvia$$b46
000176936 7001_ $$aIvanauskas, Audrius$$b47
000176936 7001_ $$aPapiris, Konstantinos$$b48
000176936 7001_ $$aBasso, Daniela$$b49
000176936 7001_ $$aArcidiacono, Paolo G$$b50
000176936 7001_ $$aIzbéki, Ferenc$$b51
000176936 7001_ $$aChammas, Roger$$b52
000176936 7001_ $$aVodicka, Pavel$$b53
000176936 7001_ $$aHackert, Thilo$$b54
000176936 7001_ $$aPasquali, Claudio$$b55
000176936 7001_ $$aPiredda, Maria L$$b56
000176936 7001_ $$aCostello-Goldring, Eithne$$b57
000176936 7001_ $$aCavestro, Giulia Martina$$b58
000176936 7001_ $$aSzentesi, Andrea$$b59
000176936 7001_ $$aTavano, Francesca$$b60
000176936 7001_ $$aWłodarczyk, Barbara$$b61
000176936 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b62$$udkfz
000176936 7001_ $$aKreivenaite, Edita$$b63
000176936 7001_ $$0P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7$$aGao, Xin$$b64$$udkfz
000176936 7001_ $$aBunduc, Stefania$$b65
000176936 7001_ $$aVermeulen, Roel C H$$b66
000176936 7001_ $$aSchneider, Martin A$$b67
000176936 7001_ $$aLatiano, Anna$$b68
000176936 7001_ $$aGioffreda, Domenica$$b69
000176936 7001_ $$aTestoni, Sabrina G G$$b70
000176936 7001_ $$aKupcinskas, Juozas$$b71
000176936 7001_ $$aLawlor, Rita T$$b72
000176936 7001_ $$aCapurso, Gabriele$$b73
000176936 7001_ $$aMalats, Núria$$b74
000176936 7001_ $$aCampa, Daniele$$b75
000176936 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b76$$eLast author$$udkfz
000176936 773__ $$0PERI:(DE-600)2606823-0$$a10.3389/fgene.2021.693933$$gVol. 12, p. 693933$$p693933$$tFrontiers in genetics$$v12$$x1664-8021$$y2021
000176936 909CO $$ooai:inrepo02.dkfz.de:176936$$pVDB
000176936 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ebb819874e9553d89bd480e6811dc0f3$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000176936 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aDeutsches Krebsforschungszentrum$$b38$$kDKFZ
000176936 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b62$$kDKFZ
000176936 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7$$aDeutsches Krebsforschungszentrum$$b64$$kDKFZ
000176936 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aDeutsches Krebsforschungszentrum$$b76$$kDKFZ
000176936 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000176936 9141_ $$y2021
000176936 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT GENET : 2019$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-05-04
000176936 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-05-04
000176936 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-05-04
000176936 9201_ $$0I:(DE-He78)C055-20160331$$kC055$$lC055 Genomische Epidemiologie$$x0
000176936 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x1
000176936 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x2
000176936 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x3
000176936 980__ $$ajournal
000176936 980__ $$aVDB
000176936 980__ $$aI:(DE-He78)C055-20160331
000176936 980__ $$aI:(DE-He78)C070-20160331
000176936 980__ $$aI:(DE-He78)C120-20160331
000176936 980__ $$aI:(DE-He78)HD01-20160331
000176936 980__ $$aUNRESTRICTED