TY  - JOUR
AU  - Lu, Ye
AU  - Corradi, Chiara
AU  - Gentiluomo, Manuel
AU  - López de Maturana, Evangelina
AU  - Theodoropoulos, George E
AU  - Roth, Susanne
AU  - Maiello, Evaristo
AU  - Morelli, Luca
AU  - Archibugi, Livia
AU  - Izbicki, Jakob R
AU  - Sarlós, Patricia
AU  - Kiudelis, Vytautas
AU  - Oliverius, Martin
AU  - Aoki, Mateus Nóbrega
AU  - Vashist, Yogesh
AU  - van Eijck, Casper H J
AU  - Gazouli, Maria
AU  - Talar-Wojnarowska, Renata
AU  - Mambrini, Andrea
AU  - Pezzilli, Raffaele
AU  - Bueno-de-Mesquita, Bas
AU  - Hegyi, Péter
AU  - Souček, Pavel
AU  - Neoptolemos, John P
AU  - Di Franco, Gregorio
AU  - Sperti, Cosimo
AU  - Kauffmann, Emanuele F
AU  - Hlaváč, Viktor
AU  - Uzunoğlu, Faik G
AU  - Ermini, Stefano
AU  - Małecka-Panas, Ewa
AU  - Lucchesi, Maurizio
AU  - Vanella, Giuseppe
AU  - Dijk, Frederike
AU  - Mohelníková-Duchoňová, Beatrice
AU  - Bambi, Franco
AU  - Petrone, Maria Chiara
AU  - Jamroziak, Krzysztof
AU  - Guo, Feng
AU  - Kolarova, Katerina
AU  - Capretti, Giovanni
AU  - Milanetto, Anna Caterina
AU  - Ginocchi, Laura
AU  - Loveček, Martin
AU  - Puzzono, Marta
AU  - van Laarhoven, Hanneke W M
AU  - Carrara, Silvia
AU  - Ivanauskas, Audrius
AU  - Papiris, Konstantinos
AU  - Basso, Daniela
AU  - Arcidiacono, Paolo G
AU  - Izbéki, Ferenc
AU  - Chammas, Roger
AU  - Vodicka, Pavel
AU  - Hackert, Thilo
AU  - Pasquali, Claudio
AU  - Piredda, Maria L
AU  - Costello-Goldring, Eithne
AU  - Cavestro, Giulia Martina
AU  - Szentesi, Andrea
AU  - Tavano, Francesca
AU  - Włodarczyk, Barbara
AU  - Brenner, Hermann
AU  - Kreivenaite, Edita
AU  - Gao, Xin
AU  - Bunduc, Stefania
AU  - Vermeulen, Roel C H
AU  - Schneider, Martin A
AU  - Latiano, Anna
AU  - Gioffreda, Domenica
AU  - Testoni, Sabrina G G
AU  - Kupcinskas, Juozas
AU  - Lawlor, Rita T
AU  - Capurso, Gabriele
AU  - Malats, Núria
AU  - Campa, Daniele
AU  - Canzian, Federico
TI  - Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.
JO  - Frontiers in genetics
VL  - 12
SN  - 1664-8021
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2021-02176
SP  - 693933
PY  - 2021
N1  - #EA:C055#LA:C055#
AB  - Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case-Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95
KW  - genetic polymorphisms (Other)
KW  - miRNA (Other)
KW  - pancreatic cancer (Other)
KW  - pancreatic ductal adenocarcinoma (Other)
KW  - susceptibility (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34527018
C2  - pmc:PMC8435735
DO  - DOI:10.3389/fgene.2021.693933
UR  - https://inrepo02.dkfz.de/record/176936
ER  -