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@ARTICLE{Lu:176936,
      author       = {Y. Lu$^*$ and C. Corradi and M. Gentiluomo and E. López de
                      Maturana and G. E. Theodoropoulos and S. Roth and E. Maiello
                      and L. Morelli and L. Archibugi and J. R. Izbicki and P.
                      Sarlós and V. Kiudelis and M. Oliverius and M. N. Aoki and
                      Y. Vashist and C. H. J. van Eijck and M. Gazouli and R.
                      Talar-Wojnarowska and A. Mambrini and R. Pezzilli and B.
                      Bueno-de-Mesquita and P. Hegyi and P. Souček and J. P.
                      Neoptolemos and G. Di Franco and C. Sperti and E. F.
                      Kauffmann and V. Hlaváč and F. G. Uzunoğlu and S. Ermini
                      and E. Małecka-Panas and M. Lucchesi and G. Vanella and F.
                      Dijk and B. Mohelníková-Duchoňová and F. Bambi and M. C.
                      Petrone and K. Jamroziak and F. Guo$^*$ and K. Kolarova and
                      G. Capretti and A. C. Milanetto and L. Ginocchi and M.
                      Loveček and M. Puzzono and H. W. M. van Laarhoven and S.
                      Carrara and A. Ivanauskas and K. Papiris and D. Basso and P.
                      G. Arcidiacono and F. Izbéki and R. Chammas and P. Vodicka
                      and T. Hackert and C. Pasquali and M. L. Piredda and E.
                      Costello-Goldring and G. M. Cavestro and A. Szentesi and F.
                      Tavano and B. Włodarczyk and H. Brenner$^*$ and E.
                      Kreivenaite and X. Gao$^*$ and S. Bunduc and R. C. H.
                      Vermeulen and M. A. Schneider and A. Latiano and D.
                      Gioffreda and S. G. G. Testoni and J. Kupcinskas and R. T.
                      Lawlor and G. Capurso and N. Malats and D. Campa and F.
                      Canzian$^*$},
      title        = {{A}ssociation of {G}enetic {V}ariants {A}ffecting
                      micro{RNA}s and {P}ancreatic {C}ancer {R}isk.},
      journal      = {Frontiers in genetics},
      volume       = {12},
      issn         = {1664-8021},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2021-02176},
      pages        = {693933},
      year         = {2021},
      note         = {#EA:C055#LA:C055#},
      abstract     = {Genetic factors play an important role in the
                      susceptibility to pancreatic cancer (PC). However,
                      established loci explain a small proportion of genetic
                      heritability for PC; therefore, more progress is needed to
                      find the missing ones. We aimed at identifying single
                      nucleotide polymorphisms (SNPs) affecting PC risk through
                      effects on micro-RNA (miRNA) function. We searched in silico
                      the genome for SNPs in miRNA seed sequences or 3 prime
                      untranslated regions (3'UTRs) of miRNA target genes.
                      Genome-wide association data of PC cases and controls from
                      the Pancreatic Cancer Cohort (PanScan) Consortium and the
                      Pancreatic Cancer Case-Control (PanC4) Consortium were
                      re-analyzed for discovery, and genotyping data from two
                      additional consortia (PanGenEU and PANDoRA) were used for
                      replication, for a total of 14,062 cases and 11,261
                      controls. None of the SNPs reached genome-wide significance
                      in the meta-analysis, but for three of them the associations
                      were in the same direction in all the study populations and
                      showed lower value of p in the meta-analyses than in the
                      discovery phase. Specifically, rs7985480 was consistently
                      associated with PC risk (OR = 1.12, $95\%$ CI 1.07-1.17, p =
                      3.03 × 10-6 in the meta-analysis). This SNP is in linkage
                      disequilibrium (LD) with rs2274048, which modulates binding
                      of various miRNAs to the 3'UTR of UCHL3, a gene involved in
                      PC progression. In conclusion, our results expand the
                      knowledge of the genetic PC risk through miRNA-related SNPs
                      and show the usefulness of functional prioritization to
                      identify genetic polymorphisms associated with PC risk.},
      keywords     = {genetic polymorphisms (Other) / miRNA (Other) / pancreatic
                      cancer (Other) / pancreatic ductal adenocarcinoma (Other) /
                      susceptibility (Other)},
      cin          = {C055 / C070 / C120 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34527018},
      pmc          = {pmc:PMC8435735},
      doi          = {10.3389/fgene.2021.693933},
      url          = {https://inrepo02.dkfz.de/record/176936},
}