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| 037 | _ | _ | |a DKFZ-2021-02189 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Baertsch, Marc-Andrea |0 0000-0002-4000-6904 |b 0 |
| 245 | _ | _ | |a Carfilzomib, Lenalidomide, and Dexamethasone Followed by Salvage Autologous Stem Cell Transplant with or without Maintenance for Relapsed or Refractory Multiple Myeloma. |
| 260 | _ | _ | |a Basel |c 2021 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1634042313_10604 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:A360# |
| 520 | _ | _ | |a Salvage high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) is a treatment option for relapsed and/or refractory multiple myeloma (RRMM). No data are available on salvage HDCT/ASCT following re-induction treatment with state-of-the-art triplet regimens. We retrospectively report on 44 patients receiving salvage HDCT/ASCT following re-induction with carfilzomib/lenalidomide/dexamethasone (KRd). All patients received frontline HDCT/ASCT with median time to progression (TTP1) of 2.9 (1.2-13.5) years, enabling paired comparison of frontline and salvage HDCT/ASCT. After re-induction and before salvage transplant, 25/44 patients (57%) attained ≥ very good partial response (VGPR), which increased to 34/44 (77%) at best response after salvage HDCT/ASCT. Median progression-free survival (PFS) was 23.3 months from salvage HDCT/ASCT. Patients with ≥ VGPR at the time of salvage HDCT/ASCT and those receiving maintenance treatment post salvage HDCT/ASCT had significantly superior PFS (hazard ratio (HR) 0.19, p = 0.001 and HR 0.20, p = 0.009). In patients achieving at least an equal depth of response before salvage HDCT/ASCT as before frontline HDCT/ASCT, PFS after salvage HDCT/ASCT was comparable to the frontline situation (p = 0.3). This is the first report of state-of-the-art triplet re-induction and salvage HDCT/ASCT for RRMM after frontline transplantation. Deep remissions achieved with KRd translate into prolonged PFS following salvage HDCT/ASCT and are enhanced by maintenance treatment. |
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| 650 | _ | 7 | |a lenalidomide maintenance |2 Other |
| 650 | _ | 7 | |a multiple myeloma |2 Other |
| 650 | _ | 7 | |a salvage autologous stem cell transplantation |2 Other |
| 650 | _ | 7 | |a salvage high-dose chemotherapy |2 Other |
| 700 | 1 | _ | |a Fougereau, Mathilde |b 1 |
| 700 | 1 | _ | |a Hielscher, Thomas |0 P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f |b 2 |u dkfz |
| 700 | 1 | _ | |a Sauer, Sandra |b 3 |
| 700 | 1 | _ | |a Breitkreutz, Iris |b 4 |
| 700 | 1 | _ | |a Jordan, Karin |b 5 |
| 700 | 1 | _ | |a Müller-Tidow, Carsten |b 6 |
| 700 | 1 | _ | |a Goldschmidt, Hartmut |b 7 |
| 700 | 1 | _ | |a Raab, Marc-Steffen |0 P:(DE-He78)1cb537e833afd985097ccfaddffb2ef3 |b 8 |u dkfz |
| 700 | 1 | _ | |a Hillengass, Jens |0 P:(DE-He78)7ccc574e713526d2a22d7acb9b2248c5 |b 9 |
| 700 | 1 | _ | |a Giesen, Nicola |0 P:(DE-He78)8dc0876dc3ed1862337d98842984727d |b 10 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.3390/cancers13184706 |g Vol. 13, no. 18, p. 4706 - |0 PERI:(DE-600)2527080-1 |n 18 |p 4706 |t Cancers |v 13 |y 2021 |x 2072-6694 |
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